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rdf:type |
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lifeskim:mentions |
umls-concept:C0010346,
umls-concept:C0017431,
umls-concept:C0037791,
umls-concept:C0079399,
umls-concept:C0079419,
umls-concept:C0205214,
umls-concept:C0205419,
umls-concept:C0314603,
umls-concept:C0812222,
umls-concept:C1704675,
umls-concept:C1882071
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-8
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pubmed:abstractText |
Defective p53-mediated apoptosis and cell cycle control have been implicated in the immunopathogenesis of Crohn's disease (CD). Since common functional variants of p53 (SNP72 G/C) and its key negative regulator mdm2 (SNP309 T/G) have been reported to affect cellular apoptotic and cell cycle arrest capacities, we assessed the effects of these variants on CD susceptibility and their relationship to NOD2/CARD15 as a well-established genetic CD risk factor.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9867
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
246-51
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pubmed:meshHeading |
pubmed-meshheading:20110711-Adult,
pubmed-meshheading:20110711-Alleles,
pubmed-meshheading:20110711-Apoptosis,
pubmed-meshheading:20110711-Case-Control Studies,
pubmed-meshheading:20110711-Confidence Intervals,
pubmed-meshheading:20110711-Crohn Disease,
pubmed-meshheading:20110711-Female,
pubmed-meshheading:20110711-Gene Expression Regulation,
pubmed-meshheading:20110711-Genetic Predisposition to Disease,
pubmed-meshheading:20110711-Genetic Variation,
pubmed-meshheading:20110711-Genotype,
pubmed-meshheading:20110711-Humans,
pubmed-meshheading:20110711-Male,
pubmed-meshheading:20110711-Middle Aged,
pubmed-meshheading:20110711-Odds Ratio,
pubmed-meshheading:20110711-Polymorphism, Single Nucleotide,
pubmed-meshheading:20110711-Prognosis,
pubmed-meshheading:20110711-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:20110711-Reference Values,
pubmed-meshheading:20110711-Risk Assessment,
pubmed-meshheading:20110711-Sex Factors,
pubmed-meshheading:20110711-Tumor Suppressor Protein p53
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pubmed:year |
2010
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pubmed:articleTitle |
Genotypic interaction and gender specificity of common genetic variants in the p53/mdm2 network in Crohn's disease.
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pubmed:affiliation |
Department of Medicine II, Saarland University Hospital, Homburg/Saar, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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