rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2010-1-29
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pubmed:abstractText |
P2X receptors are membrane ion channels activated by extracellular adenosine 5'-triphosphate (ATP) which contribute to various physiological processes. The present study describes in synovial fibroblasts (SFs) obtained from osteoarthritis (OA) patients and in SW 982 cells derived from human synovial sarcoma a pharmacological characterization of P2X(1) and P2X(3) receptors implicated in the modulation of inflammatory processes in joint diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/P2RX3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2X,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2X3,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9778
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-36
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20110693-Cell Line,
pubmed-meshheading:20110693-Dinoprostone,
pubmed-meshheading:20110693-Fibroblasts,
pubmed-meshheading:20110693-Humans,
pubmed-meshheading:20110693-Inflammation Mediators,
pubmed-meshheading:20110693-Interleukin-6,
pubmed-meshheading:20110693-NF-kappa B,
pubmed-meshheading:20110693-Osteoarthritis,
pubmed-meshheading:20110693-Phenotype,
pubmed-meshheading:20110693-Protein Binding,
pubmed-meshheading:20110693-Receptors, Purinergic P2,
pubmed-meshheading:20110693-Receptors, Purinergic P2X,
pubmed-meshheading:20110693-Receptors, Purinergic P2X3,
pubmed-meshheading:20110693-Synovial Membrane,
pubmed-meshheading:20110693-Thermodynamics,
pubmed-meshheading:20110693-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts.
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pubmed:affiliation |
Department of Clinical and Experimental Medicine, University of Ferrara, 44100 Ferrara, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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