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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-4-20
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pubmed:abstractText |
Early growth response gene-1 (Egr-1) regulates the expression of genes important to cardiovascular disease. Within atherosclerotic lesions, Egr-1 is expressed in smooth muscle cells, endothelial cells, and macrophages. Since macrophages play a pivotal role in atherosclerotic lesion initiation and progression, this study investigated the effects of Egr-1 deficiency within bone marrow-derived cells on the development of atherosclerosis in a hyperlipidaemic mouse model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Egr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboplastin,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/transforming growth factor-beta...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-9
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pubmed:meshHeading |
pubmed-meshheading:20110335-Animals,
pubmed-meshheading:20110335-Aorta, Thoracic,
pubmed-meshheading:20110335-Atherosclerosis,
pubmed-meshheading:20110335-Bone Marrow Cells,
pubmed-meshheading:20110335-Bone Marrow Transplantation,
pubmed-meshheading:20110335-Disease Models, Animal,
pubmed-meshheading:20110335-Early Growth Response Protein 1,
pubmed-meshheading:20110335-Female,
pubmed-meshheading:20110335-Gene Expression Regulation,
pubmed-meshheading:20110335-Hyperlipidemias,
pubmed-meshheading:20110335-Lipids,
pubmed-meshheading:20110335-Macrophages,
pubmed-meshheading:20110335-Mice,
pubmed-meshheading:20110335-Mice, Inbred C57BL,
pubmed-meshheading:20110335-Mice, Knockout,
pubmed-meshheading:20110335-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20110335-RNA, Messenger,
pubmed-meshheading:20110335-Radiation Chimera,
pubmed-meshheading:20110335-Receptors, LDL,
pubmed-meshheading:20110335-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:20110335-Thromboplastin,
pubmed-meshheading:20110335-Time Factors,
pubmed-meshheading:20110335-Vascular Cell Adhesion Molecule-1,
pubmed-meshheading:20110335-Whole-Body Irradiation
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pubmed:year |
2010
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pubmed:articleTitle |
Egr-1 deficiency in bone marrow-derived cells reduces atherosclerotic lesion formation in a hyperlipidaemic mouse model.
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pubmed:affiliation |
Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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