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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-5-17
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pubmed:abstractText |
Fibroblast migration plays an important role in the normal wound healing process; however, dysregulated cell migration may contribute to the progressive formation of fibrotic lesions in the diseased condition. To examine the role of focal-adhesion-kinase (FAK)-related non-kinase (FRNK) in regulation of fibrotic lung fibroblast migration, we examined cell migration, FRNK expression, and activation of focal adhesion kinase (FAK) and Rho GTPase (Rho and Rac) in primary lung fibroblasts derived from both idiopathic pulmonary fibrosis (IPF) patients and normal human controls. Fibrotic (IPF) lung fibroblasts have increased cell migration when compared to control human lung fibroblasts. FRNK expression is significantly reduced in IPF lung fibroblasts, while activation of FAK, Rho and Rac is increased in IPF lung fibroblasts. Endogenous FRNK expression is inversely correlated with FAK activation and cell migration rate in IPF lung fibroblasts. Forced exogenous FRNK expression abrogates the increased cell migration, and blocked the activation of FAK and Rho GTPase (Rho and Rac), in IPF lung fibroblasts. These data for the first time provide evidence that downregulation of endogenous FRNK plays a role in promoting cell migration through FAK and Rho GTPase in fibrotic IPF lung fibroblasts.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA109748,
http://linkedlifedata.com/resource/pubmed/grant/HL058655,
http://linkedlifedata.com/resource/pubmed/grant/HL085083,
http://linkedlifedata.com/resource/pubmed/grant/HL085324,
http://linkedlifedata.com/resource/pubmed/grant/HL095451,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA109748-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL058655-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL085083-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL085324-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL085324-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL085324-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL085324-03S1,
http://linkedlifedata.com/resource/pubmed/grant/R03 HL095451-01A1
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-10413676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-10477732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-11069767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-11587991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-12456636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-12640026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-12702722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-12791582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-12796381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-12881526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-14722604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-15077193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-15108811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-15557280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-16823799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-18303050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-18669633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-19411312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-7566154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-8423801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-8611700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-8649427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-8824286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20109444-9148935
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1090-2422
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
316
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1600-9
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20109444-Blotting, Western,
pubmed-meshheading:20109444-Cell Adhesion,
pubmed-meshheading:20109444-Cell Movement,
pubmed-meshheading:20109444-Cells, Cultured,
pubmed-meshheading:20109444-Down-Regulation,
pubmed-meshheading:20109444-Fibroblasts,
pubmed-meshheading:20109444-Fluorescent Antibody Technique,
pubmed-meshheading:20109444-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:20109444-Humans,
pubmed-meshheading:20109444-Idiopathic Pulmonary Fibrosis,
pubmed-meshheading:20109444-Lung,
pubmed-meshheading:20109444-Phenotype,
pubmed-meshheading:20109444-Protein-Tyrosine Kinases,
pubmed-meshheading:20109444-Signal Transduction,
pubmed-meshheading:20109444-rho GTP-Binding Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts.
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pubmed:affiliation |
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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