| pubmed-article:20108212 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20108212 | lifeskim:mentions | umls-concept:C0282575 | lld:lifeskim |
| pubmed-article:20108212 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20108212 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20108212 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:20108212 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20108212 | pubmed:dateCreated | 2010-1-28 | lld:pubmed |
| pubmed-article:20108212 | pubmed:abstractText | There is a tendency for the incidence of diabetes in a population to increase with an improvement in living standards. This would imply the involvement of nutritional factors in the development of diabetes, and so nutritional considerations could be a key aspect in the research and development of an effective remedy for diabetes. In this study, combined micronutrients (selenium, vitamin E, vanadium, and chromium) were orally supplemented to streptozotocin-induced diabetic mice. Results showed that combined micronutrients could decrease the high blood glucose levels (p<0.05 or p<0.01) of diabetic mice. The protective effects of combined micronutrients on structures of beta-cells in pancreatic islets of diabetic mice were observed histopathologically and ultrastructurally. In addition, the supplementation of combined micronutrients increased insulin expression by beta-cells in pancreatic islets of diabetic mice at both translational and transcriptional levels. The immune molecular mechanisms involved were preliminarily regarded as downregulation of the expression of pathogenic T-helper 1 lymphocyte (Th1) cytokine tumor necrosis factor-alpha (TNF-alpha) (p<0.01) along with upregulation of the expression of protective T-helper 2 lymphocyte Th2 cytokine interleukin 10 (IL-10) (p<0.01) which ameliorates the Th1/Th2 imbalance in diabetes. In conclusion, supplementation of combined micronutrients to diabetic mice could effectively improve disordered glucose metabolism, protect islet structures, and improve the function of beta-cells in pancreatic islets, which are affected by differential regulation of the expression of Th1/Th2 cytokines involved in the pathogenesis of diabetes. | lld:pubmed |
| pubmed-article:20108212 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20108212 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20108212 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20108212 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20108212 | pubmed:issn | 0300-9831 | lld:pubmed |
| pubmed-article:20108212 | pubmed:author | pubmed-author:SongYangY | lld:pubmed |
| pubmed-article:20108212 | pubmed:author | pubmed-author:SunYingY | lld:pubmed |
| pubmed-article:20108212 | pubmed:author | pubmed-author:TsicopoulosAn... | lld:pubmed |
| pubmed-article:20108212 | pubmed:author | pubmed-author:GaoShenS | lld:pubmed |
| pubmed-article:20108212 | pubmed:author | pubmed-author:ChangYingY | lld:pubmed |
| pubmed-article:20108212 | pubmed:author | pubmed-author:PiaoSong-LanS... | lld:pubmed |
| pubmed-article:20108212 | pubmed:author | pubmed-author:ZhengDe-MingD... | lld:pubmed |
| pubmed-article:20108212 | pubmed:author | pubmed-author:ZhangGui-Zhen... | lld:pubmed |
| pubmed-article:20108212 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:20108212 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:20108212 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20108212 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20108212 | pubmed:pagination | 104-16 | lld:pubmed |
| pubmed-article:20108212 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:20108212 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:20108212 | pubmed:articleTitle | Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice. | lld:pubmed |
| pubmed-article:20108212 | pubmed:affiliation | Department of Central Research, The Third Clinical College, Jilin University, Xiantai Street No. 126, Changchun 130033, China. | lld:pubmed |
| pubmed-article:20108212 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20108212 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20108212 | lld:pubmed |
