Linked Life Data

20108212

Source:http://linkedlifedata.com/resource/pubmed/id/20108212

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-1-28
pubmed:abstractText
There is a tendency for the incidence of diabetes in a population to increase with an improvement in living standards. This would imply the involvement of nutritional factors in the development of diabetes, and so nutritional considerations could be a key aspect in the research and development of an effective remedy for diabetes. In this study, combined micronutrients (selenium, vitamin E, vanadium, and chromium) were orally supplemented to streptozotocin-induced diabetic mice. Results showed that combined micronutrients could decrease the high blood glucose levels (p<0.05 or p<0.01) of diabetic mice. The protective effects of combined micronutrients on structures of beta-cells in pancreatic islets of diabetic mice were observed histopathologically and ultrastructurally. In addition, the supplementation of combined micronutrients increased insulin expression by beta-cells in pancreatic islets of diabetic mice at both translational and transcriptional levels. The immune molecular mechanisms involved were preliminarily regarded as downregulation of the expression of pathogenic T-helper 1 lymphocyte (Th1) cytokine tumor necrosis factor-alpha (TNF-alpha) (p<0.01) along with upregulation of the expression of protective T-helper 2 lymphocyte Th2 cytokine interleukin 10 (IL-10) (p<0.01) which ameliorates the Th1/Th2 imbalance in diabetes. In conclusion, supplementation of combined micronutrients to diabetic mice could effectively improve disordered glucose metabolism, protect islet structures, and improve the function of beta-cells in pancreatic islets, which are affected by differential regulation of the expression of Th1/Th2 cytokines involved in the pathogenesis of diabetes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0300-9831
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-16
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20108212-Animals, pubmed-meshheading:20108212-Blood Glucose, pubmed-meshheading:20108212-Chromium, pubmed-meshheading:20108212-Cytokines, pubmed-meshheading:20108212-Diabetes Mellitus, Experimental, pubmed-meshheading:20108212-Dietary Supplements, pubmed-meshheading:20108212-Immunohistochemistry, pubmed-meshheading:20108212-In Situ Hybridization, pubmed-meshheading:20108212-Insulin, pubmed-meshheading:20108212-Insulin-Secreting Cells, pubmed-meshheading:20108212-Male, pubmed-meshheading:20108212-Mice, pubmed-meshheading:20108212-Mice, Inbred C57BL, pubmed-meshheading:20108212-Micronutrients, pubmed-meshheading:20108212-Protective Agents, pubmed-meshheading:20108212-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:20108212-Selenium, pubmed-meshheading:20108212-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:20108212-Vanadium, pubmed-meshheading:20108212-Vitamin E
pubmed:year
2009
pubmed:articleTitle
Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice.
pubmed:affiliation
Department of Central Research, The Third Clinical College, Jilin University, Xiantai Street No. 126, Changchun 130033, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't