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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-4-13
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pubmed:abstractText |
Ovariectomy (OVX)-induced estrogen withdrawal resulted in both bone loss and an increase in fat. We observed elevated osteoclast (OC) formation by bone marrow-derived macrophages treated with medium conditioned by fats from OVX mice, but not from sham-operated mice. Fats from OVX mice expressed and secreted higher levels of monocyte chemoattractant protein-1 (MCP-1) than those from sham-operated mice. Increased fat resulting from estrogen deficiency is thus responsible for bone loss due to enhanced OC formation, which is, at least partly, a consequence of elevated MCP-1 production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0219-1032
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-82
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pubmed:meshHeading |
pubmed-meshheading:20108169-Adipose Tissue,
pubmed-meshheading:20108169-Animals,
pubmed-meshheading:20108169-Bone Density,
pubmed-meshheading:20108169-Bone Diseases, Metabolic,
pubmed-meshheading:20108169-Bone Resorption,
pubmed-meshheading:20108169-Cell Differentiation,
pubmed-meshheading:20108169-Cells, Cultured,
pubmed-meshheading:20108169-Chemokine CCL2,
pubmed-meshheading:20108169-Estrogens,
pubmed-meshheading:20108169-Female,
pubmed-meshheading:20108169-Femur,
pubmed-meshheading:20108169-Intra-Abdominal Fat,
pubmed-meshheading:20108169-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:20108169-Macrophages,
pubmed-meshheading:20108169-Mice,
pubmed-meshheading:20108169-Mice, Inbred C57BL,
pubmed-meshheading:20108169-Osteoclasts,
pubmed-meshheading:20108169-Ovariectomy,
pubmed-meshheading:20108169-RANK Ligand,
pubmed-meshheading:20108169-Recombinant Proteins,
pubmed-meshheading:20108169-Subcutaneous Fat,
pubmed-meshheading:20108169-Weight Gain
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pubmed:year |
2010
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pubmed:articleTitle |
Increased fat due to estrogen deficiency induces bone loss by elevating monocyte chemoattractant protein-1 (MCP-1) production.
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pubmed:affiliation |
Department of Biological Sciences (Brain Korea 21 Program) and the Immunomodulation Research Center, University of Ulsan, Ulsan, 680-749, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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