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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-5-9
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pubmed:databankReference |
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pubmed:abstractText |
We describe here the cloning of the Aplysia K+ channel AK01a.AK01a codes for a protein of 515 amino acids, shows considerable homology to other cloned potassium channels, and can be classified as a member of the ShakerK+ channel family. Expression of the AK01a channel in Xenopus oocytes produces a rapidly inactivating outward potassium current (IAK01a) resembling the A-type currents of Drosophila Shaker. Gating for this current is shifted to potentials considerably more positive than the traditional A-currents of Aplysia; we have, however, identified a novel transient potassium current (IAdepoI) in a subset of Aplysia neurons that has similar gating and pharmacological properties to IAK01a.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0270-6474
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
918-27
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2010814-Amino Acid Sequence,
pubmed-meshheading:2010814-Animals,
pubmed-meshheading:2010814-Aplysia,
pubmed-meshheading:2010814-Base Sequence,
pubmed-meshheading:2010814-Blotting, Northern,
pubmed-meshheading:2010814-Cloning, Molecular,
pubmed-meshheading:2010814-Electrochemistry,
pubmed-meshheading:2010814-Kinetics,
pubmed-meshheading:2010814-Molecular Sequence Data,
pubmed-meshheading:2010814-Oocytes,
pubmed-meshheading:2010814-Potassium Channels,
pubmed-meshheading:2010814-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2010814-Tissue Distribution,
pubmed-meshheading:2010814-Xenopus
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pubmed:year |
1991
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pubmed:articleTitle |
Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Physiology and Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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