|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0007806,
umls-concept:C0031327,
umls-concept:C0032105,
umls-concept:C0034897,
umls-concept:C0037930,
umls-concept:C0039286,
umls-concept:C0079083,
umls-concept:C0087111,
umls-concept:C0146224,
umls-concept:C0205269,
umls-concept:C0920321
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2010-8-13
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|
pubmed:abstractText |
This study was designed to ascertain the dose-limiting toxicities (DLT) and maximally tolerated doses of the combination of fixed-dose tamoxifen and carboplatin, with escalating doses of topotecan, and to determine the pharmacokinetics of topotecan in the plasma and cerebrospinal fluid.
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|
pubmed:grant |
|
|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1432-0843
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|
pubmed:author |
pubmed-author:Al-KadhimiZaidZ,
pubmed-author:ChowWarrenW,
pubmed-author:DickM FMF,
pubmed-author:DoroshowJames HJH,
pubmed-author:FrankelPaulP,
pubmed-author:JOBJ CJC,
pubmed-author:LeongLucilleL,
pubmed-author:MamelakAdamA,
pubmed-author:MargolinKimK,
pubmed-author:MorganRobert JRJ,
pubmed-author:ShibataStephenS,
pubmed-author:SomloGeorgeG,
pubmed-author:SynoldTimothyT,
pubmed-author:TwardowskiPrzemyslawP
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|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
66
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
927-33
|
|
pubmed:meshHeading |
pubmed-meshheading:20107803-Adult,
pubmed-meshheading:20107803-Aged,
pubmed-meshheading:20107803-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:20107803-Brain Neoplasms,
pubmed-meshheading:20107803-Carboplatin,
pubmed-meshheading:20107803-Dose-Response Relationship, Drug,
pubmed-meshheading:20107803-Female,
pubmed-meshheading:20107803-Humans,
pubmed-meshheading:20107803-Male,
pubmed-meshheading:20107803-Maximum Tolerated Dose,
pubmed-meshheading:20107803-Middle Aged,
pubmed-meshheading:20107803-Neoplasm Recurrence, Local,
pubmed-meshheading:20107803-Spinal Cord Neoplasms,
pubmed-meshheading:20107803-Tamoxifen,
pubmed-meshheading:20107803-Topotecan,
pubmed-meshheading:20107803-Young Adult
|
|
pubmed:year |
2010
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|
pubmed:articleTitle |
Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors.
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|
pubmed:affiliation |
Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA. rmorgan@coh.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I,
Research Support, N.I.H., Extramural
|
