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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-5-9
|
| pubmed:abstractText |
Albumin excretion rate in urine is a marker of early, reversible stages of diabetic nephropathy. Does abnormal blood rheology represent an additional risk factor in this multifactorial process? We investigated a possible link between red cell filterability and microalbuminuria during an exercise test (exercise is supposed to improve the detection of excessive microalbuminuria). 77 diabetics (27 females, 50 males, age: 15-60 yr) underwent a 20 min inframaximal progressively increasing workload on cycloergometer, rising heart rate up to 200 minus the age. Filterability of whole blood and washed red cells were measured on 5 microns polycarbonate sieves reused after ultrasonic cleaning. Whole blood filterability was found to be impaired in 35 subjects (group A) and normal in 41 (group B). Groups A and B were matched for age, sex, blood pressure, glycemic equilibrium, and duration of disease. Microalbuminuria was higher in A at rest (39.79 +/- 13.83 micrograms/min vs 12.9 +/- 3.21, p less than 0.01) and after exercise (91.80 +/- 20.79 vs 42.23 +/- 7.85, p less than 0.01). The slopes of regression lines between resting Microalbuminuria and blood pressure were greater in group A than in group B (p less than 0.01). No relationship between microalbuminuria and washed red cell filterability was detected. This study confirms on a larger scale a previous report of our team. Some hemorheologic disorders detectable with whole blood filterability (but not with washed red cell filtration) are associated with an increase in resting and postexercise microalbuminuria.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:issn |
0398-0499
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
38-42
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:2010705-Adolescent,
pubmed-meshheading:2010705-Adult,
pubmed-meshheading:2010705-Albuminuria,
pubmed-meshheading:2010705-Diabetes Mellitus, Type 1,
pubmed-meshheading:2010705-Erythrocyte Deformability,
pubmed-meshheading:2010705-Exercise Test,
pubmed-meshheading:2010705-Female,
pubmed-meshheading:2010705-Humans,
pubmed-meshheading:2010705-Male,
pubmed-meshheading:2010705-Middle Aged
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Increased albumin excretion rate during a standardized exercise-test in diabetics with lowered blood filterability.
|
| pubmed:affiliation |
Service d'Exploration Physiologique des Hormones et des Métabolismes, Hôpital Lapeyronie, Montpellier.
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| pubmed:publicationType |
Journal Article
|