Linked Life Data

20104983

Source:http://linkedlifedata.com/resource/pubmed/id/20104983

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-1-28
pubmed:abstractText
In this study we investigated in vitro and in vivo xenograft growth inhibition by crocin isolated from Kashmiri saffron (Crocus sativus). It was found that crocin decreased cell viability in DLA cells, in a concentration- and time-dependent manner. Significant increase in the lifespan of Dalton's lymphoma bearing animals was noted by 37% and 44%, respectively. Furthermore, animals given treatment before induction of cancer showed 58% increase in lifespan and there was 95.6% reduction of solid tumor in crocin treated animals on the 31st day after tumor inoculation. Crocin also showed significant impact on hematological parameters, like the hemoglobin count and numbers of lymphocytes. These findings support the conclusion that crocin from Crocus sativus has significant anti-tumor activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1513-7368
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
887-90
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Crocin from Kashmiri saffron (Crocus sativus) induces in vitro and in vivo xenograft growth inhibition of Dalton's lymphoma (DLA) in mice.
pubmed:affiliation
Department of Biotechnology and Tumor Biology, Bhoj Science College, Bhopal, India. hamid.bakshi@gmail.com
pubmed:publicationType
Journal Article, In Vitro