Linked Life Data

20104492

Source:http://linkedlifedata.com/resource/pubmed/id/20104492

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-1
pubmed:abstractText
Epithelioid hemangioendothelioma (EHE) is a low-grade, malignant vascular tumor that most commonly presents within the liver. Patients with hepatic EHE are often candidates for liver transplantation as the disease is usually multifocal at diagnosis. Although these patients achieve excellent early outcomes post-transplant, there are very few data regarding tumor markers that can further direct chemotherapy in hepatic EHE to prevent recurrent disease. The purpose of this study was to analyze the expression of the angiogenic factor vascular endothelial growth factor (VEGF) and its receptors in hepatic EHE. Six patients with hepatic EHE were assessed for liver transplantation at our center. Pathology specimens of primary and recurrent EHE were analyzed by hematoxylin and eosin staining and by immunofluorescence for VEGF, fetal liver kinase 1 (Flk-1), and fms-related tyrosine kinase 1 (Flt-1) expression. Five patients underwent liver transplantation, and 1 patient underwent liver resection. Biopsy-proven recurrent EHE occurred in 3 patients. VEGF expression was present in 100% of the EHE specimens examined, whereas Flt-1 expression was present in only 1 sample, and Flk-1 was not observed in any of the specimens. In 1 patient with recurrent hepatic EHE post-liver transplantation, a progressive increase in the VEGF fluorescence intensity and distribution was observed. In conclusion, in this series, VEGF expression was observed in all hepatic EHE specimens analyzed. These data suggest that anti-VEGF chemotherapeutic agents will be of use in patients with hepatic EHE, particularly as a means of reducing the tumor volume prior to resection, as a means of treating unresectable or metastatic disease, or as an adjuvant therapy in the setting of liver transplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1527-6473
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-7
pubmed:meshHeading
pubmed-meshheading:20104492-Adolescent, pubmed-meshheading:20104492-Adult, pubmed-meshheading:20104492-Angiogenesis Inhibitors, pubmed-meshheading:20104492-Biopsy, pubmed-meshheading:20104492-Disease-Free Survival, pubmed-meshheading:20104492-Female, pubmed-meshheading:20104492-Hemangioendothelioma, Epithelioid, pubmed-meshheading:20104492-Humans, pubmed-meshheading:20104492-Immunohistochemistry, pubmed-meshheading:20104492-Liver Neoplasms, pubmed-meshheading:20104492-Liver Transplantation, pubmed-meshheading:20104492-Male, pubmed-meshheading:20104492-Middle Aged, pubmed-meshheading:20104492-Neoplasm Recurrence, Local, pubmed-meshheading:20104492-Neovascularization, Pathologic, pubmed-meshheading:20104492-Retrospective Studies, pubmed-meshheading:20104492-Tumor Markers, Biological, pubmed-meshheading:20104492-Vascular Endothelial Growth Factor A, pubmed-meshheading:20104492-Vascular Endothelial Growth Factor Receptor-1, pubmed-meshheading:20104492-Vascular Endothelial Growth Factor Receptor-2
pubmed:year
2010
pubmed:articleTitle
Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical management.
pubmed:affiliation
Department of Surgery, University of Alberta, Edmonton, AB Canada AB T6G 2E1. juliete@ualberta.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't