Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-1
pubmed:abstractText
Posttransplant total lymphoid irradiation is a nonmyeloablative regimen that has been extensively studied in rodent models for the induction of tolerance to bone marrow and solid organ allografts. Previous studies of experimental models and clinical transplantation have used total lymphoid irradiation in combination with anti-lymphocyte-depleting reagents and donor cell infusion to promote graft acceptance. In a rat model of orthotopic liver transplantation, we demonstrated that total lymphoid irradiation alone induced long-term graft survival. Apoptotic T cells were detected in markedly higher numbers in the livers of the total lymphoid irradiation-treated group in comparison with the control group of liver allograft recipients. Intragraft CD4(+)CD25(+)FoxP3(+) cells were increased in the total lymphoid irradiation group in the first week post-transplant and remained elevated in the graft and in the spleen. Importantly, the adoptive transfer of splenocytes from recipients that received posttransplant total lymphoid irradiation prolonged the survival of donor heart grafts, but not third-party heart grafts, whereas the depletion of CD4(+)CD25(+) cells from transferred splenocytes abrogated this prolongation. We conclude that posttransplant total lymphoid irradiation significantly increases the apoptosis of T cells in the liver graft and allows the accumulation of CD4(+)CD25(+)FoxP3(+) T regulatory cells, which facilitate the generation of donor-specific tolerance.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-10532547, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-10609951, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-10807506, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-10836360, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-11266728, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-11336687, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-11375076, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-11455265, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-11869366, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-12023614, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-12070291, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-12511875, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-12884192, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-147301, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-15816877, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-16095488, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-16319383, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-16476766, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-17175224, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-17256743, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-17286616, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-17475852, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-17565321, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-17647, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-17876275, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-18192925, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-18216355, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-18216356, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-18331536, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-377595, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-3892792, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-4884735, http://linkedlifedata.com/resource/pubmed/commentcorrection/20104482-8138266
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1527-6473
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-54
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed-meshheading:20104482-Adoptive Transfer, pubmed-meshheading:20104482-Animals, pubmed-meshheading:20104482-Antigens, CD4, pubmed-meshheading:20104482-Apoptosis, pubmed-meshheading:20104482-CD8-Positive T-Lymphocytes, pubmed-meshheading:20104482-Forkhead Transcription Factors, pubmed-meshheading:20104482-Graft Survival, pubmed-meshheading:20104482-Heart Transplantation, pubmed-meshheading:20104482-Immune Tolerance, pubmed-meshheading:20104482-Interleukin-2 Receptor alpha Subunit, pubmed-meshheading:20104482-Liver Transplantation, pubmed-meshheading:20104482-Lymphocyte Culture Test, Mixed, pubmed-meshheading:20104482-Male, pubmed-meshheading:20104482-Rats, pubmed-meshheading:20104482-Rats, Inbred Lew, pubmed-meshheading:20104482-Spleen, pubmed-meshheading:20104482-T-Lymphocytes, Regulatory, pubmed-meshheading:20104482-Transplantation, Homologous
pubmed:year
2010
pubmed:articleTitle
Induced tolerance to rat liver allografts involves the apoptosis of intragraft T cells and the generation of CD4(+)CD25(+)FoxP3(+) T regulatory cells.
pubmed:affiliation
Division of Transplantation, Department of Surgery, Stanford University, Stanford, CA 94305-5492, USA.
pubmed:publicationType
Journal Article
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