Linked Life Data

20103906

Source:http://linkedlifedata.com/resource/pubmed/id/20103906

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-1-27
pubmed:abstractText
Recent cases of increasingly elderly Werner Syndrome (WS) patients have paralleled increased lifespan in the general population, however, historical temporal lifespan variations in WS have not yet been ascertained. To assess temporal changes in life-span and progeroid comorbidity in WS, all Japanese WS patients documented from 1966-2004 were analyzed for age at onset of diabetes mellitus (DM), malignancy, and death. Of 1,019 WS analyzed, average age significantly increased for all variables studied over the study period. Average age of onset of malignancy and DM in all WS increased from 35.8 to 48.8 years and from 34.9 to 39.7 years, respectively (p < 0.001), while age at death increased from 38.2 to 52.8 years (p < 0.001), vs. 71.7 to 82.7 years (p < 0.001) in the general population. Lifespan increases in WS and the general population suggest a common environmental influence. Unlike the general population, no gender-specific difference in life-span occurred in WS, suggesting a gender-specific differential environmental effect on mutated WRN. Identification of factors responsible for age differences could facilitate improvement in survival and ageing phenotypes of WS patients and the general population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1881-7823
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Secular trends towards delayed onsets of pathologies and prolonged longevities in Japanese patients with Werner syndrome.
pubmed:affiliation
Division of Anti-ageing and Longevity Sciences, Department of Clinical Engineering, Faculty of Medical Engineering, Toin University of Yokohama, 1614 Kurogane-Cho, Aoba-ku, Yokohama, Japan. goto@cc.toin.ac.jp
pubmed:publicationType
Journal Article