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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2010-6-25
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pubmed:abstractText |
BACKGROUND. The novel immunosuppressive agent AEB071 is currently being evaluated for its capability to prevent rejection after kidney transplantation as a potential adjunct to calcineurin inhibitor-based regimen. AEB071 is a selective protein kinase C inhibitor and has been shown to be well tolerated in humans. We here present extensive in vitro studies that contribute to the understanding of AEB071 effects on human lymphocyte, natural killer (NK) cell and dendritic cell (DC) action.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1460-2385
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2159-67
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pubmed:meshHeading |
pubmed-meshheading:20100729-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20100729-Cell Proliferation,
pubmed-meshheading:20100729-Cells, Cultured,
pubmed-meshheading:20100729-Cytokines,
pubmed-meshheading:20100729-Dendritic Cells,
pubmed-meshheading:20100729-Humans,
pubmed-meshheading:20100729-Immunosuppressive Agents,
pubmed-meshheading:20100729-Ionomycin,
pubmed-meshheading:20100729-K562 Cells,
pubmed-meshheading:20100729-Killer Cells, Natural,
pubmed-meshheading:20100729-Leukocytes, Mononuclear,
pubmed-meshheading:20100729-Protein Kinase C,
pubmed-meshheading:20100729-Pyrroles,
pubmed-meshheading:20100729-Quinazolines,
pubmed-meshheading:20100729-Tetradecanoylphorbol Acetate
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pubmed:year |
2010
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pubmed:articleTitle |
Effects of the new immunosuppressive agent AEB071 on human immune cells.
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pubmed:affiliation |
Department of Nephrology, Universitätsmedizin Charité Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany. mareen.matz@charite.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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