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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-2
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pubmed:abstractText |
Chronic exposure of humans to inorganic arsenic, a potent environmental oxidative stressor, is associated with incidence of type 2 diabetes (T2D). A key driver in the pathogenesis of T2D is impairment of pancreatic beta-cell function, with the hallmark of beta-cell function being glucose-stimulated insulin secretion (GSIS). Reactive oxygen species (ROS) derived from glucose metabolism serve as one of the metabolic signals for GSIS. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1552-9924
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
864-70
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20100676-Arsenic,
pubmed-meshheading:20100676-Cell Line,
pubmed-meshheading:20100676-Dose-Response Relationship, Drug,
pubmed-meshheading:20100676-Glucose,
pubmed-meshheading:20100676-Humans,
pubmed-meshheading:20100676-Insulin,
pubmed-meshheading:20100676-Insulin-Secreting Cells,
pubmed-meshheading:20100676-NF-E2 Transcription Factor,
pubmed-meshheading:20100676-Oxidative Stress,
pubmed-meshheading:20100676-Reactive Oxygen Species,
pubmed-meshheading:20100676-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress.
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pubmed:affiliation |
Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 , USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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