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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-1-26
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pubmed:abstractText |
Aortic valve stenosis (AS) is an actively regulated pathobiological process that shows some hallmarks of atherosclerosis. Apelin and its receptor, APJ, are highly expressed in the heart, and the proposed effects of the apelin-APJ system are opposite to those of the angiotensin II-AT1-receptor pathway. The role of the apelin-APJ signaling pathway in calcified aortic valve disease is unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APLN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/APLNR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0966-8519
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
644-52
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pubmed:dateRevised |
2011-6-15
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pubmed:meshHeading |
pubmed-meshheading:20099713-Adult,
pubmed-meshheading:20099713-Aged,
pubmed-meshheading:20099713-Aged, 80 and over,
pubmed-meshheading:20099713-Aortic Valve,
pubmed-meshheading:20099713-Aortic Valve Stenosis,
pubmed-meshheading:20099713-Calcinosis,
pubmed-meshheading:20099713-Case-Control Studies,
pubmed-meshheading:20099713-Down-Regulation,
pubmed-meshheading:20099713-Female,
pubmed-meshheading:20099713-Humans,
pubmed-meshheading:20099713-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:20099713-Male,
pubmed-meshheading:20099713-Middle Aged,
pubmed-meshheading:20099713-Neovascularization, Pathologic,
pubmed-meshheading:20099713-Receptor, Angiotensin, Type 1,
pubmed-meshheading:20099713-Receptor, Angiotensin, Type 2,
pubmed-meshheading:20099713-Receptors, G-Protein-Coupled,
pubmed-meshheading:20099713-Signal Transduction,
pubmed-meshheading:20099713-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Apelin and its receptor APJ in human aortic valve stenosis.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, University of Oulu, Biocenter Oulu, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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