|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0021400,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0392747,
umls-concept:C0442043,
umls-concept:C0443172,
umls-concept:C0871261,
umls-concept:C1257985,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1515021,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C1824671,
umls-concept:C2587213,
umls-concept:C2698600,
umls-concept:C2911692
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-2-16
|
|
pubmed:abstractText |
The question of which dendritic cells (DCs) respond to pulmonary antigens and cross-prime CD8(+) T cells remains controversial. We show here that influenza-specific CD8(+) T cell priming was controlled by different DCs at different times after infection. Whereas early priming was controlled by both CD103(+)CD11b(lo) and CD103(-)CD11b(hi) DCs, CD103(-)CD11b(hi) DCs dominated antigen presentation at the peak of infection. Moreover, CD103(-)CD11b(hi) DCs captured exogenous antigens in the lungs and directly cross-primed CD8(+) T cells in the draining lymph nodes without transferring antigen to CD8alpha(+) DCs. Finally, we show that CD103(-)CD11b(hi) DCs were the only DCs to express CD70 after influenza infection and that CD70 expression on CD103(-)CD11b(hi) DCs licensed them to expand CD8(+) T cell populations responding to both influenza and exogenous ovalbumin.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1529-2916
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
216-24
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:20098442-Animals,
pubmed-meshheading:20098442-Antigens, CD70,
pubmed-meshheading:20098442-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20098442-Cross-Priming,
pubmed-meshheading:20098442-Dendritic Cells,
pubmed-meshheading:20098442-Flow Cytometry,
pubmed-meshheading:20098442-Histocompatibility Antigens Class II,
pubmed-meshheading:20098442-Immunophenotyping,
pubmed-meshheading:20098442-Influenza A virus,
pubmed-meshheading:20098442-Kinetics,
pubmed-meshheading:20098442-Lymph Nodes,
pubmed-meshheading:20098442-Mice,
pubmed-meshheading:20098442-Mice, Inbred BALB C,
pubmed-meshheading:20098442-Nucleocapsid Proteins,
pubmed-meshheading:20098442-Orthomyxoviridae Infections
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza.
|
|
pubmed:affiliation |
Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester, Rochester, New York, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
