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rdf:type |
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lifeskim:mentions |
umls-concept:C0032403,
umls-concept:C0037633,
umls-concept:C0086418,
umls-concept:C0678594,
umls-concept:C0722403,
umls-concept:C1382100,
umls-concept:C1428740,
umls-concept:C1514562,
umls-concept:C1704675,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-4
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pubmed:databankReference |
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pubmed:abstractText |
Addition of poly(ADP-ribose) (PAR) is an important post-translational modification in higher eukaryotes. Several DNA repair and checkpoint proteins possess specific PAR-binding zinc-finger (PBZ) modules critical for function. Here, we present solution structures of the two PBZ modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger. By combining in vivo PAR-binding data with NMR interaction data using PAR fragments, we propose a structural basis for PBZ-PAR recognition.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-10455009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-10935642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-11016934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-14981510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-16140981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-16829982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-17353262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-18077224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-18172500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-18474613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-19043415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-19661379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20098424-19680243
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1545-9985
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-3
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20098424-Amino Acid Sequence,
pubmed-meshheading:20098424-Humans,
pubmed-meshheading:20098424-Models, Molecular,
pubmed-meshheading:20098424-Molecular Sequence Data,
pubmed-meshheading:20098424-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:20098424-Phosphoproteins,
pubmed-meshheading:20098424-Poly Adenosine Diphosphate Ribose,
pubmed-meshheading:20098424-Protein Binding,
pubmed-meshheading:20098424-Protein Structure, Tertiary,
pubmed-meshheading:20098424-Zinc Fingers
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pubmed:year |
2010
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pubmed:articleTitle |
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
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pubmed:affiliation |
MRC Laboratory of Molecular Biology, Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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