Source:http://linkedlifedata.com/resource/pubmed/id/20097245
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-3-19
|
| pubmed:abstractText |
Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and normal or low numbers of B cells, which predispose patients to recurrent infections. Peripheral blood mononuclear cells from 19 patients with CVID, and age- and sex-matched controls, were subjected to an in vitro assay of B-cell-T-cell activation and interaction, using anti-immunoglobulin (Ig)-D conjugated to dextran (alpha-delta-dex), as a polyclonal T independent type 2 antigen mimic, with and without anti-CD3/anti-CD28, as polyclonal T-cell stimuli. Stimulation of lymphocytes with either anti-CD3 or anti-CD3 plus anti-CD28 induced T-cell activation and proliferation in CVID patients who were similar to age- and sex-matched controls, but B cells of patients were significantly less activated when peripheral blood mononuclear cells were stimulated with polyclonal T-cell agonists alone. Comparison of CD86 expression in the patients with matched controls revealed that patients had low B-cell activation in response to T-cell stimuli (bystander T-cell help). In conclusion, this sample of CVID patients exhibits a defect of T-cell "help" to B cells, and/or B-cell response to T-cell help.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1879-1166
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| pubmed:author |
pubmed-author:AghamohammadiAsgharA,
pubmed-author:Asgarian-OmranHosseinH,
pubmed-author:CarlringJenniferJ,
pubmed-author:FosterRachel ARA,
pubmed-author:HeathAndrew WAW,
pubmed-author:KardarGholam AGA,
pubmed-author:LeesAndrewA,
pubmed-author:MasoumiFarimahF,
pubmed-author:PourpakZahraZ,
pubmed-author:ReadRobert CRC,
pubmed-author:RezaeiNimaN,
pubmed-author:SaghafiShivaS,
pubmed-author:SarrafnejadAbdolfattahA,
pubmed-author:SarrafzadehShokouhS,
pubmed-author:ShahrestaniTaherehT,
pubmed-author:WingJames BJB,
pubmed-author:ZareAhadA
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
355-62
|
| pubmed:meshHeading |
pubmed-meshheading:20097245-Adolescent,
pubmed-meshheading:20097245-Adult,
pubmed-meshheading:20097245-Antibodies, Monoclonal,
pubmed-meshheading:20097245-Antigens, CD,
pubmed-meshheading:20097245-B-Lymphocytes,
pubmed-meshheading:20097245-Cell Proliferation,
pubmed-meshheading:20097245-Cells, Cultured,
pubmed-meshheading:20097245-Common Variable Immunodeficiency,
pubmed-meshheading:20097245-Dextrans,
pubmed-meshheading:20097245-Female,
pubmed-meshheading:20097245-Humans,
pubmed-meshheading:20097245-Immunization,
pubmed-meshheading:20097245-Immunoglobulin D,
pubmed-meshheading:20097245-Lymphocyte Activation,
pubmed-meshheading:20097245-Male,
pubmed-meshheading:20097245-Middle Aged,
pubmed-meshheading:20097245-Paracrine Communication,
pubmed-meshheading:20097245-T-Lymphocytes
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
B-cell-T-cell activation and interaction in common variable immunodeficiency.
|
| pubmed:affiliation |
Department of Infection and Immunity, The University of Sheffield, Sheffield, UK. nima_rezaei@farabi.tums.ac.ir
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|