Linked Life Data

20093721

Source:http://linkedlifedata.com/resource/pubmed/id/20093721

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-1-22
pubmed:abstractText
Annexin A2 and S100A10 proteins form a heterotetrameric complex and belong to different families of Ca(2+)-binding proteins. Annexins are non-EF-hand-type Ca(2+)-binding proteins that exhibit Ca(2+)-dependent binding to phospholipids and membranes in various tissues. They have been implicated in many Ca(2+)-regulated processes, including regulation of membrane organization, trafficking and interact with many targets such as ion channels. S100 proteins comprise a family of small proteins characterised by the presence of two consecutive EF-hand type Ca(2+)-binding motifs, interact with ion channels and regulate diverse processes and play a role as Ca(2+) sensors. Several annexin-S100 complexes have been characterized and require calcium. In this regard, S100A10 binding to annexin A2 is an exception in that it is regulated by a post-translational modification of annexin A2 and occurs independently of calcium concentration. This review focuses on the regulatory mechanism behind annexin A2-S100A10 complex formation, its role in regulating chloride transport in health and cystic fibrosis and the potential of this mechanism to integrate calcium and cAMP signalling in airway epithelia. We propose that cAMP/PKA-dependent activation of chloride flux (through CFTR and ORCC) requires the mobilisation of a multi-protein complex involving calcium binding proteins from three different families (annexin 2, S100A10 and Calcineurin A).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0231-5882
pubmed:author
pubmed:issnType
Print
pubmed:volume
28 Spec No Focus
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
F14-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Regulation of CFTR function by annexin A2-S100A10 complex in health and disease.
pubmed:affiliation
Academic Unit of Respiratory Medicine, The University of Sheffield, Faculty of Medicine Dentistry and Health, Royal Hallamshire Hospital, Sheffield, South Yorkshire, S10 2JF, UK. r.muimo@sheffield.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't