|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2011-2-7
|
|
pubmed:abstractText |
Discoidin domain receptor 1 (DDR1) is a collagen-binding receptor tyrosine kinase which mediates the migration and proliferation of several cell types. DDR1 is expressed in vascular smooth muscle cells (SMCs) during atherosclerosis and following vascular injury, mediating cell migration and contributing to disease pathogenesis. However, very little is known about the signaling pathways activated by the DDR1 in SMCs. Therefore we have studied the involvement of Src and mitogen-activated protein kinase (MAPK) signaling pathways downstream of DDR1 in vascular SMCs.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1879-1336
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
71-6
|
|
pubmed:meshHeading |
pubmed-meshheading:20093046-Animals,
pubmed-meshheading:20093046-Blotting, Western,
pubmed-meshheading:20093046-Cell Movement,
pubmed-meshheading:20093046-Cells, Cultured,
pubmed-meshheading:20093046-Collagen Type I,
pubmed-meshheading:20093046-Humans,
pubmed-meshheading:20093046-Immunoprecipitation,
pubmed-meshheading:20093046-Mice,
pubmed-meshheading:20093046-Mice, Knockout,
pubmed-meshheading:20093046-Myocytes, Smooth Muscle,
pubmed-meshheading:20093046-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:20093046-Signal Transduction,
pubmed-meshheading:20093046-src-Family Kinases
|
|
pubmed:articleTitle |
Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src.
|
|
pubmed:affiliation |
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
