Source:http://linkedlifedata.com/resource/pubmed/id/20092996
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-10-25
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| pubmed:abstractText |
Transcription factors AP-1, nuclear factor ?B (NF-?B) and NFAT are central to brain development by regulating the expression of genes that modulate cell proliferation, differentiation, apoptosis and synaptic plasticity. This work investigated the consequences of feeding zinc-deficient and marginal zinc diets to rat dams during gestation on the modulation of AP-1, NF-?B and NFAT in fetal brain. Sprague-Dawley rats were fed from gestation day (GD) 0 a control diet ad libitum (25 ?g zinc/g diet, C), a zinc-deficient diet ad libitum (0.5 ?g zinc/g diet, ZD), the control diet in the amounts eaten by the ZD rats (restrict fed, RF) or a diet containing a marginal zinc concentration ad libitum (10 ?g zinc/g diet, MZD) until GD 19. AP-1-DNA binding was higher (50-190%) in nuclear fraction isolated from ZD, RF and MZD fetal brains compared to controls. In MZD fetal brain, high levels of activation of the upstream mitogen-activated protein kinases JNK and p38 and low levels of ERK phosphorylation were observed. Total levels of NF-?B and NFAT activation were higher or similar in the ZD and MZD groups than in controls, respectively. However, NF-?B- and NFAT-DNA binding in nuclear fractions was markedly lower in ZD and MZD fetal brain than in controls (50-80%). The latter could be related to zinc deficiency-associated alterations of the cytoskeleton, which is required for NF-?B and NFAT nuclear transport. In summary, suboptimal zinc nutrition during gestation could cause long-term effects on brain function, partially through a deregulation of transcription factors AP-1, NF-?B and NFAT.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1873-4847
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
21
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1069-75
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| pubmed:meshHeading |
pubmed-meshheading:20092996-Animals,
pubmed-meshheading:20092996-Blotting, Western,
pubmed-meshheading:20092996-Brain,
pubmed-meshheading:20092996-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:20092996-Female,
pubmed-meshheading:20092996-Fetus,
pubmed-meshheading:20092996-Gene Expression Regulation, Developmental,
pubmed-meshheading:20092996-Male,
pubmed-meshheading:20092996-Maternal Nutritional Physiological Phenomena,
pubmed-meshheading:20092996-Mitogen-Activated Protein Kinases,
pubmed-meshheading:20092996-NF-kappa B,
pubmed-meshheading:20092996-Phosphorylation,
pubmed-meshheading:20092996-Pregnancy,
pubmed-meshheading:20092996-Rats,
pubmed-meshheading:20092996-Rats, Sprague-Dawley,
pubmed-meshheading:20092996-Time Factors,
pubmed-meshheading:20092996-Transcription Factor AP-1,
pubmed-meshheading:20092996-Zinc
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| pubmed:year |
2010
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| pubmed:articleTitle |
Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-?B and NFAT in fetal brain.
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| pubmed:affiliation |
Department of Nutrition, University of California Davis, CA 95616, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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