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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-28
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pubmed:abstractText |
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by experience of a traumatic event. PTSD is often accompanied by morphological and functional changes in the hippocampus. Recently, it was reported that the hippocampal volumes of PTSD patients are relatively low. However, the mechanisms that cause such atrophy are not well understood. Single prolonged stress (SPS) is one of the animal models proposed for PTSD. The aim of this study was to reveal whether hippocampal neuronal apoptosis and the expression of apoptosis-related protein and gene occur and investigate behavioral and electrophysiological changes of hippocampi in SPS rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1743-1328
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
579-86
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pubmed:meshHeading |
pubmed-meshheading:20092675-Animals,
pubmed-meshheading:20092675-Apoptosis,
pubmed-meshheading:20092675-Avoidance Learning,
pubmed-meshheading:20092675-Disease Models, Animal,
pubmed-meshheading:20092675-Electric Stimulation,
pubmed-meshheading:20092675-Gene Expression Regulation,
pubmed-meshheading:20092675-Hippocampus,
pubmed-meshheading:20092675-In Situ Nick-End Labeling,
pubmed-meshheading:20092675-Long-Term Potentiation,
pubmed-meshheading:20092675-Male,
pubmed-meshheading:20092675-Maze Learning,
pubmed-meshheading:20092675-Microscopy, Electron, Transmission,
pubmed-meshheading:20092675-Neurons,
pubmed-meshheading:20092675-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:20092675-Psychomotor Performance,
pubmed-meshheading:20092675-Rats,
pubmed-meshheading:20092675-Rats, Wistar,
pubmed-meshheading:20092675-Reaction Time,
pubmed-meshheading:20092675-Stress Disorders, Post-Traumatic,
pubmed-meshheading:20092675-Time Factors,
pubmed-meshheading:20092675-bcl-2-Associated X Protein
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pubmed:year |
2010
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pubmed:articleTitle |
Changes of Bax, Bcl-2 and apoptosis in hippocampus in the rat model of post-traumatic stress disorder.
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pubmed:affiliation |
Department of Histology and Embryology, China Medical University, Shenyang, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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