Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-7-27
pubmed:abstractText
In 2006 an outbreak of avian influenza A(H5N1) in Turkey caused 12 human infections, including four deaths. We conducted a serological survey to determine the extent of subclinical infection caused by the outbreak. Single serum samples were collected from five individuals with avian influenza whose nasopharyngeal swabs tested positive for H5 RNA by polymerase chain reaction, 28 family contacts of the cases, 95 poultry cullers, 75 individuals known to have had contact with diseased chickens and 81 individuals living in the region with no known contact with infected chickens and/or patients. Paired serum samples were collected from 97 healthcare workers. All sera were tested for the presence of neutralizing antibodies by enzyme-linked immunoassay, haemagglutination inhibition and microneutralization assays. Only one serum sample, from a parent of an avian influenza patient, tested positive for H5N1 by microneutralization assay. This survey shows that there was minimal subclinical H5N1 infection among contacts of human cases and infected poultry in Turkey in 2006. Further, the low rate of subclinical infection following contact with diseased poultry gave further support to the reported low infectivity of the virus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1469-4409
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1274-80
pubmed:meshHeading
pubmed-meshheading:20092669-Adolescent, pubmed-meshheading:20092669-Adult, pubmed-meshheading:20092669-Aged, pubmed-meshheading:20092669-Animals, pubmed-meshheading:20092669-Antibodies, Viral, pubmed-meshheading:20092669-Child, pubmed-meshheading:20092669-Child, Preschool, pubmed-meshheading:20092669-Disease Outbreaks, pubmed-meshheading:20092669-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:20092669-Female, pubmed-meshheading:20092669-Humans, pubmed-meshheading:20092669-Infant, pubmed-meshheading:20092669-Influenza, Human, pubmed-meshheading:20092669-Influenza A Virus, H5N1 Subtype, pubmed-meshheading:20092669-Influenza in Birds, pubmed-meshheading:20092669-Male, pubmed-meshheading:20092669-Middle Aged, pubmed-meshheading:20092669-Neutralization Tests, pubmed-meshheading:20092669-Polymerase Chain Reaction, pubmed-meshheading:20092669-Poultry, pubmed-meshheading:20092669-Turkey
pubmed:year
2010
pubmed:articleTitle
Serosurveillance study on transmission of H5N1 virus during a 2006 avian influenza epidemic.
pubmed:affiliation
Hacettepe University, Department of Pediatric Infectious Diseases, Ankara, Turkey. mceyhan@hacettepe.edu.tr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't