rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
5
|
pubmed:dateCreated |
2010-3-16
|
pubmed:abstractText |
We present a case of a young girl with end-stage renal disease secondary to anti-glomerular basement membrane disease who was receiving maintenance peritoneal dialysis and developed pure red cell aplasia secondary to anti-erythropoietin (EPO) antibodies. This occurred 13 months after the initiation of EPO alfa therapy for anemia. Initially, the patient required intermittent red blood cell transfusions. After immunosuppressive therapy had been initiated with corticosteroids and cyclosporine, the EPO antibody levels decreased precipitously, associated with an increased level of endogenous EPO production. For the following 6 months, the patient maintained adequate (>10 g/dL) hemoglobin levels and did not require red cell transfusions.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1432-198X
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
25
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
971-6
|
pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20091055-Anemia,
pubmed-meshheading:20091055-Antibodies,
pubmed-meshheading:20091055-Child, Preschool,
pubmed-meshheading:20091055-Erythrocyte Transfusion,
pubmed-meshheading:20091055-Erythropoietin,
pubmed-meshheading:20091055-Female,
pubmed-meshheading:20091055-Hematinics,
pubmed-meshheading:20091055-Hemoglobins,
pubmed-meshheading:20091055-Humans,
pubmed-meshheading:20091055-Immunosuppressive Agents,
pubmed-meshheading:20091055-Kidney Failure, Chronic,
pubmed-meshheading:20091055-Recombinant Proteins,
pubmed-meshheading:20091055-Red-Cell Aplasia, Pure,
pubmed-meshheading:20091055-Renal Dialysis,
pubmed-meshheading:20091055-Time Factors,
pubmed-meshheading:20091055-Treatment Outcome
|
pubmed:year |
2010
|
pubmed:articleTitle |
Anti-erythropoietin antibodies followed by endogenous erythropoietin production in a dialysis patient.
|
pubmed:affiliation |
Department of Nephrology, Children's National Medical Center, Washington, DC 20010, USA.
|
pubmed:publicationType |
Journal Article,
Case Reports
|