Linked Life Data

20089790

Source:http://linkedlifedata.com/resource/pubmed/id/20089790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-2-22
pubmed:abstractText
The concentration or threshold of 25-hydroxyvitamin D [25(OH)D] needed to maximally suppress intact serum parathyroid hormone (iPTH) has been suggested as a measure of optimal vitamin D status. Depending upon the definition of maximal suppression of iPTH and the 2-phase regression approach used, 2 distinct clusters for a single 25(OH)D threshold have been reported: 16-20 ng/mL (40-50 nmol/L) and 30-32 ng/mL (75-80 nmol/L). To rationalize the apparently disparate published results, we compared thresholds from several regression models including a 3-phase one to estimate simultaneously 2 thresholds before and after adjusting for possible confounding for age, BMI, glomerular filtration rate, dietary calcium, and season (April-September vs. October-March) within a single data set, i.e. data from the Tufts University Sites Testing Osteoporosis Prevention/Intervention Treatment study, consisting of 181 men and 206 women (total n = 387) ages 65-87 y. Plasma 25(OH)D and serum iPTH concentrations were (mean +/- SD) 22.1 +/- 7.44 ng/mL (55.25 +/- 18.6 nmol/L) and 36.6 +/- 16.03 pg/mL (3.88 +/- 1.7 pmol/L), respectively. The 3-phase model identified 2 thresholds of 12 ng/mL (30 nmol/L) and 28 ng/mL (70 nmol/L); similar results were found from the 2-phase models evaluated, i.e. 13-20 and 27-30 ng/mL (32.5-50 and 67.5-75 nmol/L) and with previous results. Adjusting for confounding did not change the results substantially. Accordingly, the 3-phase model appears to be superior to the 2-phase approach, because it simultaneously estimates the 2 threshold clusters found from the 2-phase approaches along with estimating confidence limits. If replicated, it may be of both clinical and public health importance.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-10525714, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-10977006, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-12081814, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-15776217, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-15887867, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-15887868, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-16908915, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-16960175, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-4546706, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-8772587, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-8988915, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-9459385, http://linkedlifedata.com/resource/pubmed/commentcorrection/20089790-9504937
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1541-6100
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
595-9
pubmed:dateRevised
2011-7-25
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Three-phase model harmonizes estimates of the maximal suppression of parathyroid hormone by 25-hydroxyvitamin D in persons 65 years of age and older.
pubmed:affiliation
Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural