Source:http://linkedlifedata.com/resource/pubmed/id/20089331
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2010-3-8
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pubmed:abstractText |
In light of the increased anticancer activities of some reported copper complexes and our previous finding of nine novel anti-proliferative salicylaldehyde pyrazole hydrazone (SPH) derivatives, we prepared copper complexes of these SPH derivatives (Cu-SPHs), which turned out to be stronger growth inhibitors to A549 cells than their corresponding SPHs via inducing apoptosis. Among them, the copper complex of (E)-N'-(2-hydroxybenzylidene)-1-(4-tert-butylbenzyl)-3-phenyl-1H-pyrazole-5-carbohydrazide, termed Cu-16, exhibited an advantage in selectivity and efficacy over the others. Immunofluorescence and Western blot analyses showed an elevated protein level of integrin beta4 upon Cu-16 treatment, and knockdown of integrin beta4 significantly inhibited Cu-16 induced apoptosis in H322 cells. Taken together, the results indicate that Cu-16 promotes apoptosis in H322 cells through elevating the protein level of integrin beta4.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1768-3254
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pubmed:author | |
pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1438-46
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pubmed:meshHeading |
pubmed-meshheading:20089331-Apoptosis,
pubmed-meshheading:20089331-Blotting, Western,
pubmed-meshheading:20089331-Cell Line, Tumor,
pubmed-meshheading:20089331-Cell Proliferation,
pubmed-meshheading:20089331-Copper,
pubmed-meshheading:20089331-Fluorescent Antibody Technique,
pubmed-meshheading:20089331-Humans,
pubmed-meshheading:20089331-Hydrazones,
pubmed-meshheading:20089331-In Situ Nick-End Labeling,
pubmed-meshheading:20089331-Integrin beta4,
pubmed-meshheading:20089331-Lung Neoplasms,
pubmed-meshheading:20089331-Organometallic Compounds,
pubmed-meshheading:20089331-RNA Interference,
pubmed-meshheading:20089331-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
A novel copper complex of salicylaldehyde pyrazole hydrazone induces apoptosis through up-regulating integrin beta4 in H322 lung carcinoma cells.
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pubmed:affiliation |
Institute of Developmental Biology, School of Life Science, Shandong University, 27 Shanda South Road, Jinan 250100, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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