Linked Life Data

20088852

Source:http://linkedlifedata.com/resource/pubmed/id/20088852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-11-22
pubmed:abstractText
As a multifunctional cytokine, transforming growth factor-beta1 (TGF-?1) was detected in the utero-placental interface during early pregnancy in the pig and believed to enhance trophoblast attachment to the endometrium. In this experiment, we selected TGF-?1 as the candidate gene affecting litter size in pigs. Four polymorphic loci of TGF-?1 gene were found by PCR-SSCP (single-strand conformation polymorphism) in Large white sows (n?=?567): C?T mutation at 33nt in the intron 4; G?A mutation at 179nt in the intron 6; C?T mutation at 1043nt in the intron 6; GG?AA linkage mutations at 2490nt and 2494nt respectively. We haplotyped these SNPs as: CGCAA (denote as P) and TATGG (denote as K). The effects of three haplotypic combinations (HCs) of PP, PK and KK on litter sizes were investigated by a linear model. It was found that for the first parity litters, the least squares mean for total number born (TNB) of KK was 1.02?piglets/litter, higher than that of PK (p?<?0.05), 0.49?piglets/litter higher than that of PP (p?>?0.1). There were no significant differences between HCs on the second parity. The result indicated that KK HCs was significantly associated with pig litter size.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1439-0531
pubmed:author
pubmed:copyrightInfo
© 2010 Blackwell Verlag GmbH.
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1028-32
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Association with TGF-?1 gene polymorphisms and reproductive performance of Large white pig.
pubmed:affiliation
College of Animal Science and Technology, China Agricultural University, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't