Linked Life Data

20087995

Source:http://linkedlifedata.com/resource/pubmed/id/20087995

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-1-26
pubmed:abstractText
Quercetin and other flavonoids have been reported to exhibit both antioxidant and pro-oxidant properties. Most studies about the pro-oxidative ability were conducted in the presence of metal ions, and the essential functional moiety of quercetin responsible for the pro-oxidative effect is still unclear. In this study, we evaluated the pro-oxidative abilities in the absence of metal ions of two quercetin derivatives, i.e., quercetin-3'-O-beta-D-glucoside (1) and quercetin-3-O-beta-D-glucoside (2), by assessing DNA cleavage and HO(*)-radical production. The binding mode between these compounds and DNA was studied by fluorescence and viscometric titrations. The results showed that 1 can efficiently induce oxidative damage to plasmid DNA, while 2 shows poor activity. Both 1 and 2 bind to DNA via groove-binding. These results proved that the alpha-hydroxy-beta-oxo-alpha,beta-enone moiety contributes to the pro-oxidative activity of quercetin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1612-1880
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-44
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Who is the king? The alpha-hydroxy-beta-oxo-alpha,beta-enone moiety or the catechol B ring: relationship between the structure of quercetin derivatives and their pro-oxidative abilities.
pubmed:affiliation
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P R China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't