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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-22
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pubmed:abstractText |
Patients with diarrhea-predominant irritable bowel syndrome (IBS-D) appear to have increased intestinal permeability; it has been suggested that activation of protease-activated receptor-2 (PAR-2) receptors is responsible for this alteration. The aims of this study are to evaluate (1) if rectal (large bowel) permeability is increased in IBS-D and (2) if tryptase plays a critical role in the altered permeability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1573-2568
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2922-8
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pubmed:meshHeading |
pubmed-meshheading:20087660-Biopsy,
pubmed-meshheading:20087660-Cell Membrane Permeability,
pubmed-meshheading:20087660-Cell Polarity,
pubmed-meshheading:20087660-Colon,
pubmed-meshheading:20087660-Diarrhea,
pubmed-meshheading:20087660-Diffusion Chambers, Culture,
pubmed-meshheading:20087660-Dose-Response Relationship, Drug,
pubmed-meshheading:20087660-Horseradish Peroxidase,
pubmed-meshheading:20087660-Humans,
pubmed-meshheading:20087660-Intestinal Mucosa,
pubmed-meshheading:20087660-Irritable Bowel Syndrome,
pubmed-meshheading:20087660-Receptor, PAR-2,
pubmed-meshheading:20087660-Rectum,
pubmed-meshheading:20087660-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20087660-Tryptases
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pubmed:year |
2010
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pubmed:articleTitle |
Subjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptase.
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pubmed:affiliation |
Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
In Vitro
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