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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-5
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pubmed:abstractText |
Caspase 8 (CASP8) is an apoptosis-related cysteine peptidase involved in the death receptor pathway and likely in the mitochondrial pathway. A CASP8 promoter region six-nucleotide deletion/insertion (-652 6N ins/del) variant and a coding region D302H polymorphism are reportedly important in cancer development, but no reported study has assessed the associations of these genetic variations with risk of head and neck cancer. In a hospital-based study of non-Hispanic whites, we genotyped CASP8 -652 6N del and 302H variants in 1,023 patients with squamous cell carcinoma of the head and neck (SCCHN) and 1,052 cancer-free controls. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models. The CASP8 -652 6N del variant genotypes or haplotypes were inversely associated with SCCHN risk (adjusted OR, 0.70; 95% CI, 0.57-0.85 for the ins/del + del/del genotypes compared with the ins/ins genotype; adjusted OR, 0.73; 95% CI, 0.55-0.97 for the del-D haplotype compared with the ins-D haplotype). Furthermore, the number of the CASP8 -652 6N del (but not 302H) variant allele tended to correlate with increased levels of camptothecin-induced p53-mediated apoptosis in T lymphocytes from 170 cancer-free controls. We concluded that the CASP8 -652 6N del variant allele may contribute to the risk of developing SCCHN in non-Hispanic white populations. Further validation by population-based case-control studies and rigorous mechanistic studies is warranted.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-10688869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-10793327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-11048727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-11357141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-11606376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-1286166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-14500729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-14744432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-15180941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-15601643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-15664982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-15864269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-15878916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-16217767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-16251207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-16369175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-16721740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-17071630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-17251508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-17274053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-17293864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-17450141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-17684142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-17693666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-18287387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-18305469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-18398042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-2208109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-8306340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-9184224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20086182-9931493
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1940-6215
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
246-53
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:20086182-Apoptosis,
pubmed-meshheading:20086182-Carcinoma, Squamous Cell,
pubmed-meshheading:20086182-Caspase 8,
pubmed-meshheading:20086182-Female,
pubmed-meshheading:20086182-Genetic Predisposition to Disease,
pubmed-meshheading:20086182-Genotype,
pubmed-meshheading:20086182-Head and Neck Neoplasms,
pubmed-meshheading:20086182-Humans,
pubmed-meshheading:20086182-Male,
pubmed-meshheading:20086182-Middle Aged,
pubmed-meshheading:20086182-Mutagenesis, Insertional,
pubmed-meshheading:20086182-Neoplasm Staging,
pubmed-meshheading:20086182-Promoter Regions, Genetic,
pubmed-meshheading:20086182-Risk Factors,
pubmed-meshheading:20086182-Sequence Deletion,
pubmed-meshheading:20086182-T-Lymphocytes
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pubmed:year |
2010
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pubmed:articleTitle |
The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.
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pubmed:affiliation |
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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