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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-1-25
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pubmed:abstractText |
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/microL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1537-6613
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pubmed:author |
pubmed-author:AnsteyNicholasN,
pubmed-author:AshleyElizabethE,
pubmed-author:BarnesKaren IKI,
pubmed-author:BinhTran QuangTQ,
pubmed-author:D'AlessandroUmbertoU,
pubmed-author:DayNicholas P JNP,
pubmed-author:DorseyGrantG,
pubmed-author:GuthmannJean-PaulJP,
pubmed-author:LeeSue JSJ,
pubmed-author:MayxayMayfongM,
pubmed-author:NewtonPaul NPN,
pubmed-author:NostenFrançoisF,
pubmed-author:OlliaroPieroP,
pubmed-author:OsorioLydaL,
pubmed-author:RowlandMarkM,
pubmed-author:SmithuisFrankF,
pubmed-author:StepniewskaKasiaK,
pubmed-author:TaylorWalter R JWR,
pubmed-author:WARDA FAFJr,
pubmed-author:WhiteNicholas JNJ,
pubmed-author:de VriesPeter JPJ
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
570-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20085495-Adolescent,
pubmed-meshheading:20085495-Adult,
pubmed-meshheading:20085495-Aged,
pubmed-meshheading:20085495-Aged, 80 and over,
pubmed-meshheading:20085495-Antimalarials,
pubmed-meshheading:20085495-Artemisinins,
pubmed-meshheading:20085495-Child,
pubmed-meshheading:20085495-Child, Preschool,
pubmed-meshheading:20085495-Drug Resistance,
pubmed-meshheading:20085495-Endemic Diseases,
pubmed-meshheading:20085495-Humans,
pubmed-meshheading:20085495-Infant,
pubmed-meshheading:20085495-Kaplan-Meier Estimate,
pubmed-meshheading:20085495-Malaria, Falciparum,
pubmed-meshheading:20085495-Middle Aged,
pubmed-meshheading:20085495-Parasitemia,
pubmed-meshheading:20085495-Plasmodium falciparum,
pubmed-meshheading:20085495-Recurrence
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pubmed:year |
2010
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pubmed:articleTitle |
In vivo parasitological measures of artemisinin susceptibility.
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pubmed:affiliation |
Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand. kasia@tropmedres.ac
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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