Linked Life Data

20084792

Source:http://linkedlifedata.com/resource/pubmed/id/20084792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-1-20
pubmed:abstractText
The number of recurring genetic abnormalities recognized in acute myeloid leukemia (AML) has increased rapidly in recent years and at present, acute leukemia is probably the most extensively analyzed human cancer. Combined cytogenetic and molecular genetic studies have revealed that clonal chromosome abnormalities are present in the majority of patients with AML that are very closely, and sometimes uniquely, associated with distinct subsets of leukemia. Detailed analysis of these rearrangements indicates that in most instances chromosome rearrangements result in gene fusions leading to chimeric abnormal protein with oncogenic potential. Continued identification and characterization of genes involved in the development of leukemia has a major impact on our understanding of the molecular biology of cancer and in formulating of biologically based therapies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
2078-2101
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-15
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Acute myeloid leukemia as a genetic disease. Review article.
pubmed:affiliation
Department of Hematology, Hussein Makki Al-Juma Centre for Specialised Surgery, State of Kuwait.
pubmed:publicationType
Journal Article, Review