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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-6-15
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pubmed:abstractText |
Nonalcoholic steatohepatitis (NASH) is a feature of metabolic syndrome. Advanced glycation end-products (AGEs) are formed by the Maillard reaction, which contributes to aging and to certain pathological complications of diabetes. A recent study has suggested that glyceraldehyde-derived AGEs (Glycer-AGEs) are elevated in the sera of patients with NASH. Furthermore, immunohistochemistry of Glycer-AGEs showed intense staining in the livers of patients with NASH. The present study aimed to examine the effect of intracellular Glycer-AGEs on hepatocellular carcinoma (Hep3B) cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1435-5922
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
646-55
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pubmed:meshHeading |
pubmed-meshheading:20084527-Blotting, Western,
pubmed-meshheading:20084527-C-Reactive Protein,
pubmed-meshheading:20084527-Carcinoma, Hepatocellular,
pubmed-meshheading:20084527-Cell Death,
pubmed-meshheading:20084527-Cell Line, Tumor,
pubmed-meshheading:20084527-Cell Survival,
pubmed-meshheading:20084527-Dose-Response Relationship, Drug,
pubmed-meshheading:20084527-Fatty Liver,
pubmed-meshheading:20084527-Glyceraldehyde,
pubmed-meshheading:20084527-Glycosylation End Products, Advanced,
pubmed-meshheading:20084527-HSC70 Heat-Shock Proteins,
pubmed-meshheading:20084527-Humans,
pubmed-meshheading:20084527-Inflammation,
pubmed-meshheading:20084527-Liver Neoplasms,
pubmed-meshheading:20084527-Microscopy, Confocal,
pubmed-meshheading:20084527-RNA, Messenger,
pubmed-meshheading:20084527-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20084527-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
The formation of intracellular glyceraldehyde-derived advanced glycation end-products and cytotoxicity.
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pubmed:affiliation |
Department of Pathophysiological Science, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, 920-1181, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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