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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-2-3
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pubmed:abstractText |
The cytochrome P450 (CYP) 2C19 isoenzyme plays an important role in clopidogrel metabolization. A recently explored CYP2C19*17 allelic variant has been linked to increased transcriptional activity, resulting in extensive metabolization of CYP2C19 substrates, which may lead to an enhanced platelet response to clopidogrel treatment. The aim of this study was to assess the impact of CYP2C19*17 on ADP-induced platelet aggregation, the risk of bleeding, and stent thrombosis in clopidogrel-treated patients undergoing percutaneous coronary intervention.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
512-8
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pubmed:dateRevised |
2010-10-8
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pubmed:meshHeading |
pubmed-meshheading:20083681-Aged,
pubmed-meshheading:20083681-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:20083681-Coronary Artery Disease,
pubmed-meshheading:20083681-Coronary Thrombosis,
pubmed-meshheading:20083681-Female,
pubmed-meshheading:20083681-Follow-Up Studies,
pubmed-meshheading:20083681-Gene Frequency,
pubmed-meshheading:20083681-Genotype,
pubmed-meshheading:20083681-Hemorrhage,
pubmed-meshheading:20083681-Heterozygote,
pubmed-meshheading:20083681-Humans,
pubmed-meshheading:20083681-Male,
pubmed-meshheading:20083681-Middle Aged,
pubmed-meshheading:20083681-Multivariate Analysis,
pubmed-meshheading:20083681-Platelet Aggregation,
pubmed-meshheading:20083681-Platelet Aggregation Inhibitors,
pubmed-meshheading:20083681-Polymorphism, Genetic,
pubmed-meshheading:20083681-Risk Factors,
pubmed-meshheading:20083681-Stents,
pubmed-meshheading:20083681-Ticlopidine,
pubmed-meshheading:20083681-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement.
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pubmed:affiliation |
Deutsches Herzzentrum München, Lazarettstrasse 36, 80636 München, Germany. dirk@sibbing.net
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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