Source:http://linkedlifedata.com/resource/pubmed/id/20083674
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-2-4
|
| pubmed:abstractText |
Early immune response to the largely used Mycobacterium bovis bacillus Calmette-Guérin (BCG) intradermal vaccine remains ill defined. Three days after BCG inoculation into the mouse ear, in addition to neutrophils infiltrating skin, we observed CD11b(+)Ly-6C(int)Ly-6G(-) myeloid cells. Neutrophil depletion markedly enhanced their recruitment. These cells differed from inflammatory monocytes and required MyD88-dependent BCG-specific signals to invade skin, whereas neutrophil influx was MyD88 independent. Upon BCG phagocytosis, CD11b(+)Ly-6C(int)Ly-6G(-) cells produced NO, which required the IL-1 receptor. Despite NO production, they were unable to kill BCG or the nonpathogenic Mycobacterium smegmatis. However, they markedly impaired T cell priming in the draining lymph node. Their elimination by all-trans retinoid acid treatment increased the number of IFN-gamma-producing CD4 T cells. Thus, BCG vaccination recruits innate myeloid-derived suppressor cells, akin to mouse tumor-infiltrating cells. These propathogenic cells dampen the early T cell response and might facilitate BCG persistence.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1550-6606
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
184
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2038-47
|
| pubmed:meshHeading |
pubmed-meshheading:20083674-Animals,
pubmed-meshheading:20083674-BCG Vaccine,
pubmed-meshheading:20083674-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20083674-Cell Movement,
pubmed-meshheading:20083674-Female,
pubmed-meshheading:20083674-Immunity, Innate,
pubmed-meshheading:20083674-Lymph Nodes,
pubmed-meshheading:20083674-Lymphocyte Activation,
pubmed-meshheading:20083674-Mice,
pubmed-meshheading:20083674-Mice, Inbred BALB C,
pubmed-meshheading:20083674-Mice, Inbred C57BL,
pubmed-meshheading:20083674-Mice, Knockout,
pubmed-meshheading:20083674-Mice, Transgenic,
pubmed-meshheading:20083674-Myeloid Cells,
pubmed-meshheading:20083674-Neutrophils,
pubmed-meshheading:20083674-Nitric Oxide,
pubmed-meshheading:20083674-Receptors, Interleukin-1,
pubmed-meshheading:20083674-T-Lymphocyte Subsets
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Mycobacterium bovis bacillus Calmette-Guérin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo T cell priming via IL-1R-dependent nitric oxide production.
|
| pubmed:affiliation |
Institut Pasteur Unité Génétique Mycobactérienne, Université Pierre et Marie Curie-Paris 6, AP-HP Groupe Hospitalier Pitié-Salpétrière Service d'Immunologie, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|