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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-5-13
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pubmed:abstractText |
Reciprocal plasticity exists between endothelial and mesenchymal lineages. For instance, mature endothelial cells adopt a smooth muscle-like phenotype through transforming growth factor beta-1 (TGFbeta1)-driven endothelial-to-mesenchymal transdifferentiation (EndMT). Peripheral blood contains circulating endothelial progenitor cells of which the endothelial colony-forming cells (ECFCs) harbour stem cell-like properties. Given the plasticity between endothelial and mesenchymal lineages and the stem cell-like properties of ECFCs, we hypothesized that ECFCs can give rise to smooth muscle-like progeny.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ANGPT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/ID3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Smad2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/TGF-beta type I receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
506-15
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pubmed:meshHeading |
pubmed-meshheading:20083576-Angiopoietin-1,
pubmed-meshheading:20083576-Biological Markers,
pubmed-meshheading:20083576-Cell Lineage,
pubmed-meshheading:20083576-Cell Transdifferentiation,
pubmed-meshheading:20083576-Cells, Cultured,
pubmed-meshheading:20083576-Cytoskeleton,
pubmed-meshheading:20083576-Endothelial Cells,
pubmed-meshheading:20083576-Fetal Blood,
pubmed-meshheading:20083576-Fibroblast Growth Factor 2,
pubmed-meshheading:20083576-Humans,
pubmed-meshheading:20083576-Inhibitor of Differentiation Proteins,
pubmed-meshheading:20083576-Muscle, Smooth, Vascular,
pubmed-meshheading:20083576-Myocytes, Smooth Muscle,
pubmed-meshheading:20083576-Neoplasm Proteins,
pubmed-meshheading:20083576-Neovascularization, Physiologic,
pubmed-meshheading:20083576-Paracrine Communication,
pubmed-meshheading:20083576-Phenotype,
pubmed-meshheading:20083576-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20083576-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:20083576-Signal Transduction,
pubmed-meshheading:20083576-Smad2 Protein,
pubmed-meshheading:20083576-Stem Cells,
pubmed-meshheading:20083576-Time Factors,
pubmed-meshheading:20083576-Transforming Growth Factor beta1,
pubmed-meshheading:20083576-Vasoconstriction
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pubmed:year |
2010
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pubmed:articleTitle |
Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny.
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pubmed:affiliation |
Laboratory for Cardiovascular Regenerative Medicine , NL-9713GZ Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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