Linked Life Data

20082973

Source:http://linkedlifedata.com/resource/pubmed/id/20082973

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-1-19
pubmed:abstractText
Positron emission tomography has been widely exploited to study the progression of Parkinson's disease (PD) and the associated motor impairment. It is however now increasingly appreciated that much of the disability of PD arises from non-motor complications, including cognitive and behavioural problems, sleep disturbances, pain and autonomic dysfunction. Recent studies in which these problems were investigated are reviewed in this paper. Although interesting findings are emerging, much work remains to be done. This will depend upon the ability to investigate non dopaminergic mechanisms as well as extra-striatal release of dopamine and the capacity to assess the impact of behaviourally relevant stimuli on neurotransmitter release and on networks of brain activation. Functional imaging studies, including PET, SPECT and functional MRI may provide valuable insights into the pathophysiology of disorders such as Parkinson's disease (PD), where structural changes are limited. Until recently, the major focus of such studies has been either on patterns of cerebral blood flow or glucose metabolism at rest or following a variety of activation paradigms, or on studies of the dopamine (DA) system. This article will review non-motor aspects of PD. While there is an enormous volume of imaging literature on the motor aspects of PD or motoric complications, that will not be addressed here.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1873-5126
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S13-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Functional imaging studies of non-motoric manifestations of Parkinson's Disease.
pubmed:affiliation
Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada. jstoessl@interchange.ubc.ca
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't