Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-1-27
pubmed:abstractText
Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 x 10(-17); ratio of insulin to glucose area under the curve, P = 1.3 x 10(-16)) and diminished incretin effect (n = 804; P = 4.3 x 10(-4)). We also identified variants at ADCY5 (rs2877716, P = 4.2 x 10(-16)), VPS13C (rs17271305, P = 4.1 x 10(-8)), GCKR (rs1260326, P = 7.1 x 10(-11)) and TCF7L2 (rs7903146, P = 4.2 x 10(-10)) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)).
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/077016, http://linkedlifedata.com/resource/pubmed/grant/088885, http://linkedlifedata.com/resource/pubmed/grant/K23 DK065978-05, http://linkedlifedata.com/resource/pubmed/grant/K24 DK080140-04, http://linkedlifedata.com/resource/pubmed/grant/K24 DK080140-05, http://linkedlifedata.com/resource/pubmed/grant/M01 RR000052-46, http://linkedlifedata.com/resource/pubmed/grant/M01 RR001066-26, http://linkedlifedata.com/resource/pubmed/grant/M01 RR016500-08, http://linkedlifedata.com/resource/pubmed/grant/N01 HC015103, http://linkedlifedata.com/resource/pubmed/grant/N01 HC025195, http://linkedlifedata.com/resource/pubmed/grant/N01 HC035129, http://linkedlifedata.com/resource/pubmed/grant/N01 HC045133, http://linkedlifedata.com/resource/pubmed/grant/N01 HC055015, http://linkedlifedata.com/resource/pubmed/grant/N01 HC055016, http://linkedlifedata.com/resource/pubmed/grant/N01 HC055018, http://linkedlifedata.com/resource/pubmed/grant/N01 HC055019, http://linkedlifedata.com/resource/pubmed/grant/N01 HC055020, http://linkedlifedata.com/resource/pubmed/grant/N01 HC055021, http://linkedlifedata.com/resource/pubmed/grant/N01 HC055022, http://linkedlifedata.com/resource/pubmed/grant/N01 HC055222, http://linkedlifedata.com/resource/pubmed/grant/N01 HC075150, http://linkedlifedata.com/resource/pubmed/grant/N01 HC085079, http://linkedlifedata.com/resource/pubmed/grant/N01 HC085080, http://linkedlifedata.com/resource/pubmed/grant/N01 HC085081, http://linkedlifedata.com/resource/pubmed/grant/N01 HC085082, http://linkedlifedata.com/resource/pubmed/grant/N01 HC085083, http://linkedlifedata.com/resource/pubmed/grant/N01 HC085084, http://linkedlifedata.com/resource/pubmed/grant/N01 HC085085, http://linkedlifedata.com/resource/pubmed/grant/N01 HC085086, http://linkedlifedata.com/resource/pubmed/grant/N02 HL64278, http://linkedlifedata.com/resource/pubmed/grant/P01 CA087969-12, http://linkedlifedata.com/resource/pubmed/grant/P30 DK072488-06, http://linkedlifedata.com/resource/pubmed/grant/P60 DK079637-04, http://linkedlifedata.com/resource/pubmed/grant/R01 AG013196-16, http://linkedlifedata.com/resource/pubmed/grant/R01 DK054261-09, http://linkedlifedata.com/resource/pubmed/grant/R01 DK058845-11, http://linkedlifedata.com/resource/pubmed/grant/R01 DK062370-05, http://linkedlifedata.com/resource/pubmed/grant/R01 DK069922-03, http://linkedlifedata.com/resource/pubmed/grant/R01 DK072193-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DK078616-03, http://linkedlifedata.com/resource/pubmed/grant/R01 HL036310-21, http://linkedlifedata.com/resource/pubmed/grant/R01 HL059367-10, http://linkedlifedata.com/resource/pubmed/grant/R01 HL086694-03, http://linkedlifedata.com/resource/pubmed/grant/R01 HL087641-03, http://linkedlifedata.com/resource/pubmed/grant/R01 HL087652-03, http://linkedlifedata.com/resource/pubmed/grant/U01 HG004399-02, http://linkedlifedata.com/resource/pubmed/grant/U01 HG004402-02, http://linkedlifedata.com/resource/pubmed/grant/U01 HL072515-06, http://linkedlifedata.com/resource/pubmed/grant/U01 HL080295-04, http://linkedlifedata.com/resource/pubmed/grant/U54 DA021519-04, http://linkedlifedata.com/resource/pubmed/grant/Z01 HG000024-14
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-10611300, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-11679427, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-12351489, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-12652354, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-12898014, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-14763905, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-15498460, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-15505121, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-16415884, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-17200703, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-17624916, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-17671651, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-18008060, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-18080106, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-18451265, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-18521185, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-18640588, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-18678614, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-18952314, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-19060907, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-19060909, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-19369657, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-20437211, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-3522621, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-3899825, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-8922354, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-9267997, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-9794107, http://linkedlifedata.com/resource/pubmed/commentcorrection/20081857-9920805
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
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