Linked Life Data

20081822

Source:http://linkedlifedata.com/resource/pubmed/id/20081822

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-1-18
pubmed:abstractText
The ability of the mammalian brain to undergo experience-based adaptations is among its most important and fascinating properties. Such plasticity is reflected in the capacity of neuronal activity to continuously modify the neural circuitry that underlies thought, feeling and behavior. The locus of this plasticity occurs at the level of synapses, the specialized junctions where one neuron receives chemical signals from another. Synaptic connections become stronger or weaker in response to specific patterns of activity. This activity drives regulated changes in the neurotransmitter released by presynaptic neurons and in the receptors localized on postsynaptic neurons. Detailed studies of these receptors have advanced our understanding of synaptic plasticity. However, many key questions remain unresolved, and over the past decade innovative chemical approaches have emerged to tackle them. Here we review these chemical tools and their application to unraveling the molecular basis of synaptic plasticity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1552-4469
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-97
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
AMPA receptors and synaptic plasticity: a chemist's perspective.
pubmed:affiliation
Department of Pharmaceutical Chemistry, University of California, San Francisco, California, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural