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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-27
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pubmed:abstractText |
Inflammatory bowel disease (IBD) is characterized by recurrent and severe gastrointestinal inflammation. Activation of inflammatory cells, such as TH17 lymphocytes, and/or deficiency of regulatory T cells (Treg) are responsible for the pathogenesis of IBD. As an acute phase reactant, heme oxygenase-1 (HO-1) has been shown to play an anti-inflammatory and immunomodulatory role in many disease processes. In this study, we used a dextran sulfate sodium (DSS)-induced murine colitis model to investigate the effect of upregulating HO-1 by hemin on the development of colonic inflammation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1536-4801
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
132-9
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pubmed:meshHeading |
pubmed-meshheading:20081544-Animals,
pubmed-meshheading:20081544-Anti-Inflammatory Agents,
pubmed-meshheading:20081544-Apoptosis,
pubmed-meshheading:20081544-Colitis,
pubmed-meshheading:20081544-Colon,
pubmed-meshheading:20081544-Dextran Sulfate,
pubmed-meshheading:20081544-Female,
pubmed-meshheading:20081544-Heme Oxygenase-1,
pubmed-meshheading:20081544-Hemin,
pubmed-meshheading:20081544-Inflammation Mediators,
pubmed-meshheading:20081544-Interleukin-17,
pubmed-meshheading:20081544-Intestinal Mucosa,
pubmed-meshheading:20081544-Metalloporphyrins,
pubmed-meshheading:20081544-Mice,
pubmed-meshheading:20081544-Mice, Inbred BALB C,
pubmed-meshheading:20081544-Models, Animal,
pubmed-meshheading:20081544-Protoporphyrins,
pubmed-meshheading:20081544-Severity of Illness Index,
pubmed-meshheading:20081544-T-Lymphocytes, Regulatory,
pubmed-meshheading:20081544-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Hemin exerts multiple protective mechanisms and attenuates dextran sulfate sodium-induced colitis.
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pubmed:affiliation |
Department of Pediatrics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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