Linked Life Data

20080841

Source:http://linkedlifedata.com/resource/pubmed/id/20080841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-3-5
pubmed:abstractText
Context: Cytokine polymorphisms and dietary fat composition may influence the risk of the metabolic syndrome (MetS). Objective: The objective of the study was to determine the relationship between lymphotoxin-alpha (LTA), TNF-alpha, and IL-6 gene polymorphisms with MetS risk and investigate whether plasma fatty acid composition, a biomarker of dietary fat intake, modulated these associations. Design: Polymorphisms (LTA rs915654, TNF-alpha rs1800629, IL-6 rs1800797), biochemical measurements, and plasma fatty acids were determined in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). Results: LTA rs915654 minor A allele carriers and TNF-alpha rs1800629 major G allele homozygotes had increased MetS risk [odds ratio (OR) 1.37 (confidence interval [CI] 1.12-1.66), P = 0.002 and OR 1.35 (CI 1.08-1.70), P = 0.009] compared with their TT homozygotes and A allele carriers. Possession of the IL-6 rs1800797 GG genotype by the LTA and TNF-alpha risk genotype carriers further increased risk of the MetS [OR 2.10 (CI 1.19-3.71) P = 0.009], fasting hyperglycemia [OR 2.65 (CI 1.12-6.28), P = 0.027], high systolic blood pressure [OR 1.99 (CI 1.07-3.72), P = 0.03], and abdominal obesity [OR 1.52 (CI 1.01-2.28), P = 0.04]. Plasma polyunsaturated to saturated fat ratio exacerbated these effects; subjects in the lowest 50th percentile had even greater risk of the MetS [OR 4.40 (CI 1.55-12.45), P = 0.005], fasting hyperglycemia, high systolic blood pressure, and abdominal obesity (P < 0.05). Conclusions: LTA, TNF-alpha, and IL-6 genotype interactions increased MetS risk, which was further exacerbated by a low plasma polyunsaturated to saturated fat exposure, indicating important modulation of genetic risk by dietary fat exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1945-7197
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1386-94
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20080841-Alleles, pubmed-meshheading:20080841-C-Reactive Protein, pubmed-meshheading:20080841-Case-Control Studies, pubmed-meshheading:20080841-Dietary Fats, pubmed-meshheading:20080841-Fatty Acids, pubmed-meshheading:20080841-Genetic Predisposition to Disease, pubmed-meshheading:20080841-Genotype, pubmed-meshheading:20080841-Humans, pubmed-meshheading:20080841-Insulin, pubmed-meshheading:20080841-Interleukin-6, pubmed-meshheading:20080841-Lymphotoxin-alpha, pubmed-meshheading:20080841-Metabolic Syndrome X, pubmed-meshheading:20080841-Polymorphism, Genetic, pubmed-meshheading:20080841-Prospective Studies, pubmed-meshheading:20080841-Regression Analysis, pubmed-meshheading:20080841-Risk Factors, pubmed-meshheading:20080841-Tumor Necrosis Factor-alpha, pubmed-meshheading:20080841-Waist Circumference
pubmed:year
2010
pubmed:articleTitle
Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components.
pubmed:affiliation
Nutrigenomics Research Group, University College Dublin School of Public Health and Population Science, University College Dublin Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't