Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-3-1
pubmed:abstractText
We have shown previously that exacerbation of corneal scarring (CS) in HSV-1 glycoprotein K (gK) immunized mice was associated with CD8+ T cells. In this study, we investigated the type and the nature of the immune responses that are involved in the exacerbation of CS in gK-immunized animals. BALB/c mice were vaccinated with baculovirus expressed gK, gD, or mock-immunized. Twenty-one days after the third immunization, mice were ocularly infected with 2 x 10(5) PFU/eye of virulent HSV-1 strain McKrae. Infiltration of the cornea by CD4+, CD8+, CD25+, CD4+CD25+, CD8+CD25+, CD19+, CD40+, CD40L+, CD62L+, CD95+, B7-1+, B7-2+, MHC-I+, and MHC-II+ cells was monitored by immunohistochemistry, qRT-PCR and FACS at various times post-infection (PI). This study demonstrated for the first time that the presence of CD8+CD25+ T cells in the cornea is correlated with exacerbation of CS in the gK-immunized group.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-10090358, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-10438816, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-10482598, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-10647992, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-10774588, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-10958985, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-11188989, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-11604589, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-11901196, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-11981829, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-12070024, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-12481946, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-12576029, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-12609846, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-12844494, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-12893750, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-1313845, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-1351475, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-1370438, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-1499347, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15048066, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15194658, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15271801, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15319456, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15447720, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15512961, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15817260, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15862167, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15883173, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-15972638, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-1664126, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-17380159, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-17460278, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-17499382, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-17898051, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-17960132, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-18056169, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-187060, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-19022917, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-19168902, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-19397878, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-2170289, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-2536358, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-2834445, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-2839594, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-2990101, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-2995573, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-3005858, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-3030632, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-6206144, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-6443690, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7534202, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7534203, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7541826, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7636985, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7687302, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7769723, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7775113, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7981152, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7983727, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-7997323, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-8098778, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-8138996, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-8139020, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-8976723, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-9152241, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-9301533, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-9371974, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-9478893, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-9544579, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-9557652, http://linkedlifedata.com/resource/pubmed/commentcorrection/20079918-9824497
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
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