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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-5-11
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pubmed:abstractText |
Cortical glutamate levels are elevated in bipolar disorder, but the interpretation of this increase is unclear because glutamate has metabolic as well as neurotransmitter roles. We investigated this by measuring vesicular glutamate transporter 1 (VGluT1) expression, which reflects activity at glutamate synapses. We also measured netrin-G1 and netrin-G2 messenger RNAs because these genes are involved in the formation and plasticity of glutamatergic connections.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1873-2402
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1010-6
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pubmed:dateRevised |
2011-3-3
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pubmed:meshHeading |
pubmed-meshheading:20079890-Adult,
pubmed-meshheading:20079890-Aged,
pubmed-meshheading:20079890-Analysis of Variance,
pubmed-meshheading:20079890-Bipolar Disorder,
pubmed-meshheading:20079890-Female,
pubmed-meshheading:20079890-Functional Laterality,
pubmed-meshheading:20079890-GPI-Linked Proteins,
pubmed-meshheading:20079890-Genotype,
pubmed-meshheading:20079890-Glutamic Acid,
pubmed-meshheading:20079890-Glycoproteins,
pubmed-meshheading:20079890-Gyrus Cinguli,
pubmed-meshheading:20079890-Humans,
pubmed-meshheading:20079890-In Situ Hybridization,
pubmed-meshheading:20079890-Male,
pubmed-meshheading:20079890-Middle Aged,
pubmed-meshheading:20079890-Nerve Tissue Proteins,
pubmed-meshheading:20079890-Neuronal Plasticity,
pubmed-meshheading:20079890-Neurons,
pubmed-meshheading:20079890-Presynaptic Terminals,
pubmed-meshheading:20079890-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20079890-Schizophrenia,
pubmed-meshheading:20079890-Synaptic Transmission,
pubmed-meshheading:20079890-Vesicular Glutamate Transport Protein 1
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pubmed:year |
2010
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pubmed:articleTitle |
Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder.
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pubmed:affiliation |
Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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