Source:http://linkedlifedata.com/resource/pubmed/id/20079863
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2010-5-10
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pubmed:abstractText |
We report the results of a single-center, prospective evaluation for iron overload and subsequent treatment in 147 adult allogeneic hematopoietic cell transplantation (HCT) recipients who survived beyond 1 year after transplantation. Patients were screened by serum ferritin level; those with ferritin >1000 ng/mL underwent liver R2 magnetic resonance imaging to estimate liver iron concentration (LIC; normal < or =1.8 mg/g). Patients with significant iron overload (defined as LIC > or =5 mg/g), based on physician and patient preference, were offered observation only, phlebotomy, or enrollment in a pilot study of deferasirox. Sixteen patients had significant iron overload. Their median age was 51 years (range, 29-64 years), and they had survived a median of 21 months (range, 12-114 months). All 16 patients were transfusion-independent at study enrollment. Five patients received no treatment (median LIC, 6.4 mg/g; range, 5.1-28.3 mg/g), 8 underwent phlebotomy (median LIC, 13.1 mg/g; range, 7.8-43.0 mg/g), and 3 received daily deferasirox 20 mg/kg/day orally for 6 months (LIC, 6.3, 9.0, and 19.9 mg/g). Two patients had abnormal liver function tests, and 1 patient each had cirrhosis and unexplained congestive heart failure; all 4 of these patients underwent phlebotomy. Follow-up serum ferritin concentrations decreased spontaneously in 4 patients in the observation-only arm. Phlebotomy was generally well tolerated. Deferasirox also was well tolerated and led to decreased LIC after 6 months of therapy in all 3 patients. Phlebotomy is feasible in the majority of allogeneic HCT recipients who have survived for > or =1 year after HCT and have significant iron overload. Although the number of subjects is small, deferasirox may be a safe and effective alternative for allogeneic HCT survivors with iron overload who cannot undergo phlebotomy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Ferritins,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/deferasirox
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1523-6536
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2010 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
832-7
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pubmed:meshHeading |
pubmed-meshheading:20079863-Adult,
pubmed-meshheading:20079863-Benzoic Acids,
pubmed-meshheading:20079863-Female,
pubmed-meshheading:20079863-Ferritins,
pubmed-meshheading:20079863-Heart,
pubmed-meshheading:20079863-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:20079863-Hemoglobins,
pubmed-meshheading:20079863-Humans,
pubmed-meshheading:20079863-Iron,
pubmed-meshheading:20079863-Iron Overload,
pubmed-meshheading:20079863-Liver,
pubmed-meshheading:20079863-Male,
pubmed-meshheading:20079863-Middle Aged,
pubmed-meshheading:20079863-Phlebotomy,
pubmed-meshheading:20079863-Transplantation, Homologous,
pubmed-meshheading:20079863-Treatment Outcome,
pubmed-meshheading:20079863-Triazoles
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pubmed:year |
2010
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pubmed:articleTitle |
A prospective study of iron overload management in allogeneic hematopoietic cell transplantation survivors.
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pubmed:affiliation |
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA. majha001@umn.edu
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pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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