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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-6-1
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pubmed:abstractText |
The PKC-beta inhibitor ruboxistaurin (RBX or LY333531) prevents diabetic renal and retinal microvascular complications. However, the effect of RBX on diabetic cardiac microvascular dysfunction is still unclear. In this study, we aimed to investigate the effects and mechanisms of RBX treatment upon cardiac endothelial barrier dysfunction in high glucose states. We demonstrated RBX treatment suppressed high glucose induced PKC-betaII activation and phosphorylation of beta-catenin in vivo and in vitro experiments. Meanwhile, RBX treatment protected cardiac microvascular barrier function in diabetic animals and monolayer barrier function of cultured cardiac microvascular endothelial cells (CMECs), reproducing the same effect as PKC-betaII siRNA. These results provide new insight into protective properties of PKC-beta inhibitor against cardiac endothelial barrier dysfunction. PKC-beta inhibitor RBX prevented chronic cardiac microvascular barrier dysfunction and improved endothelial cell-cell junctional function in high glucose states.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Lanthanum,
http://linkedlifedata.com/resource/pubmed/chemical/Maleimides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/cadherin 5,
http://linkedlifedata.com/resource/pubmed/chemical/lanthanide nitrate,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C beta,
http://linkedlifedata.com/resource/pubmed/chemical/ruboxistaurin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9319
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pubmed:author |
pubmed-author:CaoFengF,
pubmed-author:DEH NHN,
pubmed-author:DiChunxiaC,
pubmed-author:HwangAndrewA,
pubmed-author:LeeAndrewA,
pubmed-author:RongqingZhangZ,
pubmed-author:SunDongdongD,
pubmed-author:WangHaichangH,
pubmed-author:WeiLipingL,
pubmed-author:XXX,
pubmed-author:YinZhiyongZ
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-65
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pubmed:meshHeading |
pubmed-meshheading:20079359-Animals,
pubmed-meshheading:20079359-Antigens, CD,
pubmed-meshheading:20079359-Cadherins,
pubmed-meshheading:20079359-Capillary Permeability,
pubmed-meshheading:20079359-Cells, Cultured,
pubmed-meshheading:20079359-Coronary Vessels,
pubmed-meshheading:20079359-Diabetes Mellitus, Experimental,
pubmed-meshheading:20079359-Electric Impedance,
pubmed-meshheading:20079359-Endothelial Cells,
pubmed-meshheading:20079359-Glucose,
pubmed-meshheading:20079359-Heart,
pubmed-meshheading:20079359-Heart Diseases,
pubmed-meshheading:20079359-Indoles,
pubmed-meshheading:20079359-Intercellular Junctions,
pubmed-meshheading:20079359-Lanthanum,
pubmed-meshheading:20079359-Male,
pubmed-meshheading:20079359-Maleimides,
pubmed-meshheading:20079359-Myocardium,
pubmed-meshheading:20079359-Perfusion,
pubmed-meshheading:20079359-Protein Kinase C,
pubmed-meshheading:20079359-Protein Kinase Inhibitors,
pubmed-meshheading:20079359-RNA, Small Interfering,
pubmed-meshheading:20079359-Rats,
pubmed-meshheading:20079359-Rats, Sprague-Dawley,
pubmed-meshheading:20079359-beta Catenin
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pubmed:year |
2010
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pubmed:articleTitle |
A PKC-beta inhibitor treatment reverses cardiac microvascular barrier dysfunction in diabetic rats.
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pubmed:affiliation |
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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