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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-2-12
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pubmed:abstractText |
Genetic factors play a role in chronic obstructive pulmonary disease (COPD) but are poorly understood. A number of candidate genes have been proposed on the basis of the pathogenesis of COPD. These include the matrix metalloproteinase (MMP) genes which play a role in tissue remodelling and fit in with the protease--antiprotease imbalance theory for the cause of COPD. Previous genetic studies of MMPs in COPD have had inadequate coverage of the genes, and have reported conflicting associations of both single nucleotide polymorphisms (SNPs) and SNP haplotypes, plausibly due to under-powered studies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-10712992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-11254539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-11708786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-11875051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-1458541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-15290652,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-15498369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-15596677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-15723202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-16126934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-16278826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-16308335,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-16676616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-16690673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-16773582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-16845089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-17054776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-17554300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-17765526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-17906092,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20078883-9302297
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
pubmed-author:BiçerEnderE,
pubmed-author:ChappellSallyS,
pubmed-author:DalyLeslieL,
pubmed-author:DonnellySeamas CSC,
pubmed-author:Guetta-BaranesTamarT,
pubmed-author:HaqImranI,
pubmed-author:HiemstraPieter SPS,
pubmed-author:JohnsonSimon RSR,
pubmed-author:KalshekerNoorN,
pubmed-author:KeatingsVeraV,
pubmed-author:MacNeeWilliamW,
pubmed-author:MillarAnn BAB,
pubmed-author:MiniatiMassimoM,
pubmed-author:MontiSimonettaS,
pubmed-author:MorganKevinK,
pubmed-author:O'ConnorClare MCM,
pubmed-author:RabinovichRobertoR,
pubmed-author:RocaJosepJ,
pubmed-author:StolkJanJ
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20078883-Aged,
pubmed-meshheading:20078883-Case-Control Studies,
pubmed-meshheading:20078883-Female,
pubmed-meshheading:20078883-Genetic Association Studies,
pubmed-meshheading:20078883-Genetic Predisposition to Disease,
pubmed-meshheading:20078883-Genotype,
pubmed-meshheading:20078883-Haplotypes,
pubmed-meshheading:20078883-Humans,
pubmed-meshheading:20078883-Male,
pubmed-meshheading:20078883-Matrix Metalloproteinase 1,
pubmed-meshheading:20078883-Matrix Metalloproteinase 12,
pubmed-meshheading:20078883-Matrix Metalloproteinase 9,
pubmed-meshheading:20078883-Middle Aged,
pubmed-meshheading:20078883-Polymorphism, Single Nucleotide,
pubmed-meshheading:20078883-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:20078883-Severity of Illness Index
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pubmed:year |
2010
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pubmed:articleTitle |
Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.
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pubmed:affiliation |
School of Molecular Medical Sciences, Institute of Genetics, Queen's Medical Centre, University of Nottingham, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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