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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1978-1-27
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pubmed:abstractText |
Histochemical studies were performed on signet-ring cells in surgically resected gastric carcinomas from 64 patients. On the basis of periodic acid-Schiff reactivity of the intracellular mucin, the signet-ring cells were classified as type A (immature), type B (intermediate), or type C (mature). Different staining reactions to Alcian blue at pH 2.5 enabled type C cells to be subclassified as C-1 or C-2. In 63 cases (98.4%), intense leucine naphthylamidase (LNAase) activity was found histochemically in the cytoplasm of nearly all cancer cells except type C-2. Localization of LNAase activity in the cytoplasm was confirmed by conventional biochemical assay. From the present results, histochemical characteristics of signet-ring cell carcinoma are discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1599-604
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:200755-Adenocarcinoma, Mucinous,
pubmed-meshheading:200755-Cytoplasm,
pubmed-meshheading:200755-Epithelium,
pubmed-meshheading:200755-Female,
pubmed-meshheading:200755-Humans,
pubmed-meshheading:200755-Leucyl Aminopeptidase,
pubmed-meshheading:200755-Male,
pubmed-meshheading:200755-Stomach Neoplasms
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pubmed:year |
1977
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pubmed:articleTitle |
Cytoplasmic leucine naphthylamidase activity expressed in signet-ring cell carcinoma of the stomach.
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pubmed:publicationType |
Journal Article
|