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rdf:type |
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lifeskim:mentions |
umls-concept:C0025914,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0026809,
umls-concept:C0027651,
umls-concept:C0205421,
umls-concept:C0332162,
umls-concept:C0449258,
umls-concept:C1704788,
umls-concept:C1879547,
umls-concept:C2347443
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-15
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pubmed:abstractText |
Akt plays a central role in regulating tumor cell survival and cell cycle progression and is regarded as a promising therapeutic target. We used genetically defined mouse models that develop spontaneous tumors exhibiting activated Akt to determine if Akt inhibition by GSK690693 is effective in the treatment of cancer. The broad long-term objective of this project was to use preclinical cancer models with precisely defined genetic lesions to elucidate the efficacy of targeting Akt with GSK690693.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-11752445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-12649204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-12884297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-15015494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-16095999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-16288292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-16299534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-16452206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-16585156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-17334390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-17363557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-18316591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-18381444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-18800763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-19064730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-19118049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-19497851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-19530243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-197531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20075391-8634990
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
486-96
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:20075391-Animals,
pubmed-meshheading:20075391-Antineoplastic Agents,
pubmed-meshheading:20075391-Cell Transformation, Neoplastic,
pubmed-meshheading:20075391-Disease Models, Animal,
pubmed-meshheading:20075391-Disease Progression,
pubmed-meshheading:20075391-Drug Evaluation, Preclinical,
pubmed-meshheading:20075391-Enzyme Activation,
pubmed-meshheading:20075391-Female,
pubmed-meshheading:20075391-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:20075391-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20075391-Mice,
pubmed-meshheading:20075391-Mice, Transgenic,
pubmed-meshheading:20075391-Neoplasm Transplantation,
pubmed-meshheading:20075391-Neoplasms,
pubmed-meshheading:20075391-Oncogene Protein v-akt,
pubmed-meshheading:20075391-Oxadiazoles,
pubmed-meshheading:20075391-Protein Kinase Inhibitors,
pubmed-meshheading:20075391-Tumor Cells, Cultured
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pubmed:year |
2010
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pubmed:articleTitle |
GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.
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pubmed:affiliation |
Women's Cancer, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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